Results 81 to 90 of about 3,996,783 (390)

Making a diagnosis in severe cutaneous drug hypersensitivity reactions.

Current Opinion in Allergy and Clinical Immunology, 2019
PURPOSE OF REVIEW Severe cutaneous adverse reactions (SCAR) are relatively uncommon but can be life-threatening. This review focuses on the nonanaphylactic (non-IgE-mediated) phenotypes of drug hypersensitivity, with specific reference to diagnosis and ...
M. Ardern-Jones, M. Mockenhaupt
semanticscholar   +1 more source

Stimuli‐Responsive Materials for Biomedical Applications

Advanced Materials, EarlyView.
Stimulus‐responsive materials (SRMs) hold great promise for use in a wide range of biomedical applications. This review covers four stimulus modalities, namely, electrical, optical, magnetic, and ultrasound, and their associated SRMs. It provides a summary of the materials in each modality, their development, and current research perspectives.
Adriana Teixeira do Nascimento, Paul R. Stoddart, Toon Goris, Miriam Kael, Richard Manasseh, Karen Alt, Jurie Tashkandi, Byung Chul Kim, Simon E Moulton   +8 more
wiley   +1 more source

Identification of drug-specific public TCR driving severe cutaneous adverse reactions

Nature Communications, 2019
Severe cutaneous adverse reactions (SCAR) is a T cell-mediated, potentially lethal drug hypersensitivity (DH). Here, the authors identify a carbamazepine-specific TCR common among patients with carbamazepine-induced SCAR that confers SCAR-like pathology ...
Ren-You Pan, Mu-Tzu Chu, Chuang-Wei Wang, Yun-Shien Lee, Francois Lemonnier, Aaron W. Michels, Ryan Schutte, David A. Ostrov, Chun-Bing Chen, Elizabeth Jane Phillips, Simon Alexander Mallal, Maja Mockenhaupt, Teresa Bellón, Wichittra Tassaneeyakul, Katie D. White, Jean-Claude Roujeau, Wen-Hung Chung, Shuen-Iu Hung   +17 more
doaj   +1 more source

Profile of sugammadex for reversal of neuromuscular blockade in the elderly: Current perspectives [PDF]

, 2017
The number of elderly patients is increasing worldwide. This will have a significant impact on the practice of anesthesia in future decades. Anesthesiologists must provide care for an increasing number of elderly patients, who have an elevated risk of ...
Bertoncello, Francesco, Carron, Michele, Ieppariello, Giovanna   +2 more
core   +1 more source

Immune dysregulation increases the incidence of delayed‐type drug hypersensitivity reactions

Allergy. European Journal of Allergy and Clinical Immunology, 2019
Delayed‐type, T cell–mediated, drug hypersensitivity reactions are a serious unwanted manifestation of drug exposure that develops in a small percentage of the human population.
D. Naisbitt, Anna Olsson-Brown, Andrew Gibson, Xiaoli Meng, M. Ogese, A. Tailor, Paul Thomson   +6 more
semanticscholar   +1 more source

Artificial Intelligence‐Driven Nanoarchitectonics for Smart Targeted Drug Delivery

Advanced Materials, EarlyView.
This perspective introduces an artificial intelligence (AI)‐driven nanoarchitectonics framework for targeted drug delivery, combining database‐guided nanocarrier design, machine learning (ML)‐assisted surface engineering with a designed targeting system, and in silico modeling for dynamic optimization.
Hayeon Bae, Hyunsub Ji, Konstantin Konstantinov, Ronald Sluyter, Katsuhiko Ariga, Yong Ho Kim, Jung Ho Kim   +6 more
wiley   +1 more source

Purinergic mechanosensory transduction and visceral pain [PDF]

, 2009
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Burnstock, G
core   +3 more sources

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors [PDF]

, 2019
Alcohol produces both stimulant and sedative effects in humans and rodents. In humans, alcohol abuse disorder is associated with a higher stimulant and lower sedative responses to alcohol.
Bocarsly, Miriam E., da Silva e Silva, Daniel, Dobbs, Lauren K., Kolb, Vanessa, Luderman, Kathryn D., Rubinstein, Marcelo, Shashikiran, Sannidhi, Sibley, David R., Álvarez, Verónica Alicia   +8 more
core   +1 more source

Drug hypersensitivity in HIV infection.

Current Opinion in Allergy and Clinical Immunology, 2019
PURPOSE OF REVIEW Immune-mediated adverse drug reactions (IM-ADRs) are many times more common in HIV-infected patients. Usual offending drugs include antiretroviral and antiinfectives, but the burden of specific drug IM-ADRs is population-specific ...
J. Peter, Phuti Choshi, R. Lehloenya
semanticscholar   +1 more source