Results 91 to 100 of about 1,989,460 (302)
Analytical and Computational Modeling of Sustained-Release Drug Implants in the Vitreous Humor. [PDF]
J Heat Transfer, 2021 Khoobyar A +4 more
europepmc +1 more source
Western Hemisphere Drug Policy Commission [website]
, 2021 Website of the Western Hemisphere Drug Policy Commission (WHDPC), charged to "evaluate a range of US counternarcotics programs in the Americas and then make recommendations to improve them" -- including a recording and transcript of the group's hearing ...
United States. Western Hemisphere Drug Policy Commission.
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
, 2014 BackgroundGlycine powder air-polishing (GPAP) has the potential to effectively erase biofilms and may improve the treatment efficacy of peri-implant mucositis.
Cao, Jie +11 more
core +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Effectiveness Bank Bulletin [Mortality profile of naltrexone implants] [PDF]
, 2012 Favorable mortality profile of naltrexone implants for opiate addiction. Reece A.S. Journal of Addictive Diseases: 2010, 29, p. 30–50. Few treatments for opiate addiction arouse as much controversy as naltrexone implants.
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Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
EVA implants for controlled drug delivery to the inner ear
International Journal of Pharmaceutics: XThis study evaluated the potential of poly(ethylene vinyl acetate) (EVA) copolymers as matrix formers in miniaturised implants, allowing to achieve controlled drug delivery into the inner ear.
Y. Bedulho das Lages +9 more
doaj +1 more source
Development of Implants for Prolonged Drug delivery
British Journal of Pharmacy, 2019 Despite being a popular and convenient route of drug delivery, the oral route has a number of disadvantages. Polymeric sub-dermal implants offer an alternative delivery route that may circumvent many of these challenges.
Sarah Anne Stewart +2 more
doaj +1 more source