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Implantable Systems for Drug Delivery to the Brain
Therapeutic Delivery, 2017Most diseases and disorders of the brain require long-term therapy and a constant supply of drugs. Implantable drug-delivery systems provide long-term, sustained drug delivery in the brain. The present review discusses different type of implantable systems such as solid implants, in situ forming implants, in situ forming microparticles, depot ...
Hemlata, Kaurav, Deepak N, Kapoor
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Drug-implantable cardioverter–defibrillator interactions
Expert Review of Cardiovascular Therapy, 2010Antiarrhythmic drugs are commonly used synergistically with implantable cardioverter defibrillators in the management of ventricular and supraventricular arrhythmias. However, these drugs may directly or indirectly interact with device function. In addition, expanding indications for implantable cardioverter defibrillators, particularly in patients ...
Roger, Beadle +2 more
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2014
Aseptic loosening continues to limit long-term survival of prosthesis implant. The biological pathway leading to osteolysis is not understood completely. Interfacial membranes from clinically failed arthroplasties and in vitro models have demonstrated that macrophages are activated by wear debris and release various potent resorbing mediators.
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Aseptic loosening continues to limit long-term survival of prosthesis implant. The biological pathway leading to osteolysis is not understood completely. Interfacial membranes from clinically failed arthroplasties and in vitro models have demonstrated that macrophages are activated by wear debris and release various potent resorbing mediators.
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An Implantable Drug-delivery System on a Chip
Current Topics in Medicinal Chemistry, 2015An implantable system for drug delivery provides a new strategy for drug therapy, and typically involves a microfluidic chip produced with micro or nano-technology. Implantable systems have the flexibility to conform various schemes of drug release, including zero order, pulsatile, and on demand dosing, as opposed to a standard sustained release ...
Meng-Shiue, Lee +2 more
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Implantable microchips for controlled drug delivery
The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2005We report on the development of an implantable drug delivery system capable of delivering multiple individual doses. This product controls the release of potent therapeutic compounds that might otherwise require frequent injections. The system will provide stable, hermetic storage of therapeutic drugs, such as proteins and peptides, in solid, liquid ...
J M, Maloney, J T, Santini
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Miniaturized systems, known as implantable drug delivery systems, are used to administer medicinal medicines to specific sites within the body. They are made of biocompatible substances that enclose the drug payload and control its kinetics of release, enabling sustained delivery.
Jagruti L. Desai +5 more
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Jagruti L. Desai +5 more
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Drug Delivery Systems 4. Implants in Drug Delivery
The Journal of Clinical Pharmacology, 1990In comparison with many of the other drug delivery systems, implantable pumps and implants for variable rate delivery are at a crude stage of development. Although exceptions exist, the typical implantable pump consists of an electromechanically complex mechanism to regulate drug delivery from a percutaneous refillable reservoir, while power to drive ...
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Lipid implants as drug delivery systems
Expert Opinion on Drug Delivery, 2008The parenteral controlled delivery of acid-labile drugs (e.g., proteins) is difficult, because the standard polymer poly(lactic-co-glycolic acid) used to control drug release upon parenteral administration degrades into shorter chain acids, creating acidic microclimates. Lipid implants do not show this disadvantage.
Frauke, Kreye +2 more
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Drug Confinement and Delivery in Ceramic Implants
Drug Metabolism Letters, 2007Ordered silica-based mesoporous materials could be specially designed and chemically modified for the adsorption of drugs that would be locally released. The drug adsorption and release kinetics are controlled by several factors such as pore size, volume, architecture and chemistry of the silica walls.
María, Vallet-Regí +3 more
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Cochlear implantation: an opportunity for drug development
Drug Discovery Today, 2010For many years, the fields of inner ear pharmacology and hearing devices have progressed in parallel with limited interaction. Recently, there has been a considerable advancement in our understanding of the inner ear and its pathologies. Cochlear implantation is now being adapted for patients with considerable residual hearing but minimal benefit from ...
Hinrich, Staecker +2 more
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