Results 141 to 150 of about 5,201,027 (314)
Drug-related and drug-misuse deaths 2008-2018.
, 2020 There were 189 drug-related deaths registered in Northern Ireland in 2018. Half (95) of these deaths were of men aged 25-44. These are some of the findings of the statistics published today by the Northern Ireland Statistics and Research Agency (NISRA).
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FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
Financial Risk in the Biotechnology Industry [PDF]
The biotechnology industry has been an engine of innovation for the U.S. healthcare system and, more generally, the U.S. economy. It is by far the most research intensive industry in the U.S.
John A. Vernon, Joseph H. Golec
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Perspectives on drugs: Internet-based drug treatment. [PDF]
, 2014 The Internet is now recognised as a plausible vehicle for delivering drug and alcohol education, prevention and treatment programmes in a range of settings.
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GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
The Diffusion of Science-Driven Drug Discovery: Organizational Change in Pharmaceutical Research [PDF]
Recent work linking the adoption of key organizational practices to productivity raises an important question: if adoption increases productivity so dramatically, why does adoption across an industry take so long? This paper explores this question in the
Scott Stern +2 more
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FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
DRLS, drug establishment registration and drug listing instruction booklet.
, 1991 Shipping list no.: 91-422-P.At head of title: DRLS, Drug Registration and Listing System.Mode of access ...
Center for Drug Evaluation and Research (U.S.). Drug Listing Branch.
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FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
Exposing drug industry funding of UK patient organisations.
BMJ, 2019 Ozieranski P, Rickard E, Mulinari S.
europepmc +2 more sources