Results 211 to 220 of about 7,440,138 (398)

Drug firms hype disease as sales ploy, industry chief claims [PDF]

, 2002
R. Moynihan
openalex   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Drug Residues in Dairy Cattle Industry: Epidemiological Evaluation of Factors Influencing Their Occurrence

, 1987
John B. Kaneene, Alwynelle S. Ahl
openalex   +1 more source

Evidence b(i)ased medicine--selective reporting from studies sponsored by pharmaceutical industry: review of studies in new drug applications [PDF]

, 2003
Hans Melander
openalex   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Regulation of exosomes as biologic medicines: Regulatory challenges faced in exosome development and manufacturing processes

Clinical and Translational Science
With advances in medical technology, extracellular vesicles, also known as exosomes, are gaining widespread attention because of their potential therapeutic applications.
Chun‐Kai Wang, Teng‐Huang Tsai, Chung‐Hsi Lee   +2 more
doaj   +1 more source

Reverse Degree-Based Topological Indices and QSPR Analysis of Cancer Drugs [PDF]

arXiv
A topological index of a graph $G$ is a numerical quantity that describes its topology. Reverse degree-based topological indices play an important role in finding topological descriptors. Azacitidine, Decitabine, and Guadecitabine are hypomethylating agents which are used for the treatment of patients with higher-risk myelodysplastic syndromes, acute ...
arxiv  

Industry Practices and Compliance with U.S. Food and Drug Administration Guidelines among California Sprout Firms [PDF]

, 2003
Jennifer L. Thomas, Mary S. Palumbo, Jeff Farrar, Thomas B. Farver, Dean O. Cliver   +4 more
openalex   +1 more source

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Regional consistency evaluation and sample size calculation under two MRCTs [PDF]

arXiv
Multi-regional clinical trial (MRCT) has been common practice for drug development and global registration. The FDA guidance "Demonstrating Substantial Evidence of Effectiveness for Human Drug and Biological Products Guidance for Industry" (FDA, 2019) requires that substantial evidence of effectiveness of a drug/biologic product to be demonstrated for ...
arxiv