Results 191 to 200 of about 3,913,962 (299)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Artificial intelligence-powered chatbots in search engines: a cross-sectional study on the quality and risks of drug information for patients. [PDF]

BMJ Qual Saf
Andrikyan W, Sametinger SM, Kosfeld F, Jung-Poppe L, Fromm MF, Maas R, Nicolaus HF.   +6 more
europepmc   +1 more source

Value of a web-based pediatric drug information system to prevent serious adverse drug reactions in child and adolescent psychiatry. [PDF]

J Neural Transm (Vienna), 2023
Fekete S, Kulpok C, Taurines R, Egberts K, Geissler J, Gerlach M, Malonga Makosi D, König J, Urschitz MS, Toni I, Neubert A, Romanos M.   +11 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Health Literacy, Label Comprehension, and Consumer Perceptions of Quasi-Drug Information Among Korean Adults: A Cross-Sectional Study. [PDF]

Risk Manag Healthc Policy
Ko Y, Kim HJ, Lee SM.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Establishment of a Drug Information Unit and Pharmacovigilance Cell in a Provincial Hospital of Nepal: Implementation of the 2015 Hospital Pharmacy Service Guidelines. [PDF]

Hosp Pharm
Pathak N, Rasaili A, Barma S, Khatiwada D, Raila A, Gautam DR, Shrestha P, Dhungana S, Shrestha S.   +8 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

RxTx and Micromedex

Journal of the Canadian Health Libraries Association, 2017
Kelly Hatch, Shawn Hendrikx
doaj   +1 more source

Characterization of patients with a snakebite presenting to healthcare facilities and reported to poison and drug information centers-Arizona, 2017-2021. [PDF]

Clin Toxicol (Phila)
Mitchell CL, Smelski G, Schmid K, Roland M, Christenberry M, Ellingson KD, Brooks DE, Komatsu K, Dudley S, Shirazi F, Cullen TA.   +10 more
europepmc   +1 more source