Results 61 to 70 of about 2,222,749 (351)

Hypotensive Response to Angiotensin II Type 2 Receptor Stimulation in the Rostral Ventrolateral Medulla Requires Functional GABA-A Receptors

Frontiers in Neuroscience, 2017
Objectives: Angiotensin II, glutamate and gamma-aminobutyric acid (GABA) interact within the rostral ventrolateral medulla (RVLM) and the paraventricular nucleus (PVN) modulating the central regulation of blood pressure and sympathetic tone.
Laura Légat, Laura Légat, Laura Légat, Sofie Brouwers, Sofie Brouwers, Sofie Brouwers, Ilse J. Smolders, Alain G. Dupont, Alain G. Dupont, Alain G. Dupont   +9 more
doaj   +1 more source

AMRFinderPlus and the Reference Gene Catalog facilitate examination of the genomic links among antimicrobial resistance, stress response, and virulence

Scientific Reports, 2021
Antimicrobial resistance (AMR) is a significant public health threat. With the rise of affordable whole genome sequencing, in silico approaches to assessing AMR gene content can be used to detect known resistance mechanisms and potentially identify novel
Michael Feldgarden, Vyacheslav Brover, Narjol Gonzalez-Escalona, Jonathan G. Frye, Julie Haendiges, Daniel H. Haft, Maria Hoffmann, James B. Pettengill, Arjun B. Prasad, Glenn E. Tillman, Gregory H. Tyson, William Klimke   +11 more
doaj   +1 more source

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Hypersensitivity reactions due to North American pit viper antivenom administration and confirmed elevation of alpha-gal IgE

Toxicology Communications
The two current antivenom products available in the United States (US) for North American pit viper envenomation include ovine-derived Crotalidae polyvalent immune Fab (FabAV, Crofab®) and equine-derived Crotalidae Immune (F(ab′)2, Anavip®).
William Banner, Kristie Edelen, L. Claire Epperson, Eszter Moore   +3 more
doaj   +1 more source

Ultra‐high‐field pharmacological functional MRI of dopamine D1 receptor‐related interventions in anesthetized rats

Pharmacology Research & Perspectives, 2023
The dopamine D1 receptor (D1R) is associated with schizophrenia, Parkinson's disease, and attention deficit hyperactivity disorder. Although the receptor is considered a therapeutic target for these diseases, its neurophysiological function has not been ...
Yuka Kimura, Shunsuke Nakazawa, Kantaro Nishigori, Yuki Mori, Junji Ichihara, Yoshichika Yoshioka   +5 more
doaj   +1 more source

Pharma Bulletin - Spring 2005 [PDF]

, 2005
FDA to Create Drug Safety Board In February 2005, the Food and Drug Administration (FDA) announced that it will create a new independent Drug Safety Oversight Board (DSB) to oversee the management of drug safety issues within the Center for Drug ...
Baker, Hollie, Barry, Robert, Burling, James, Heller, Mark, Kim, Suyong   +4 more
core   +1 more source

Using Electronic Drug Monitor Feedback to Improve Adherence to Antiretroviral Therapy Among HIV-Positive Patients in China [PDF]

, 2009
Effective antiretroviral therapy (ART) requires excellent adherence. Little is known about how to improve ART adherence in many HIV/AIDS-affected countries, including China.
DeSilva, Mary Bachman, Gill, Christopher J., Hamer, Davidson H., Li, Tao, Sabin, Lora L., Wilson, Ira B., Xu, Keyi, Zhang, Jianbo   +7 more
core   +3 more sources

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

Comprehensive User Engagement Sites (CUES) in Philadelphia: A Constructive Proposal [PDF]

, 2018
This paper is a study about Philadelphia’s comprehensive user engagement sites (CUESs) as the authors address and examine issues related to the upcoming implementation of a CUES while seeking solutions for its disputed questions and plans. Beginning with
Clark, Peter, Cooney, Kevin, DiMeglio, M., Dubensky, J., Gulati, S., Lathrop, S., Lee, Marvin J. H., Minupuri, A., Nguyen, Olivia, Patel, P., Schadt, Sam A., Umapathy, S., Zheng, S.   +12 more
core  

Spatial Concentration of Opioid Overdose Deaths in Indianapolis: An Application of the Law of Crime Concentration at Place to a Public Health Epidemic [PDF]

, 2019
The law of crime concentration at place has become a criminological axiom and the foundation for one of the strongest evidence-based policing strategies to date.
Carter, Jeremy G., Mohler, George, Ray, Bradley   +2 more
core   +1 more source