Results 91 to 100 of about 2,627,867 (322)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Findings from the DUMA program: internet access, and frequency and nature of use among police detainees [PDF]

Examining access to and the extent of engagement with the Internet in illicit drug-using populations may provide an indication of the extent to which the online illicit drug market is usurping the physical illicit drug market, according to this report ...
Eileen Patterson, Susan Goldsmid
core  

Parental Substance Use in New Hampshire: Who Cares for the Children? [PDF]

, 2018
In this brief, author Kristin Smith examines parental substance use and who cares for children when their parents cannot. It uses data from the New Hampshire Department of Health and Human Services’ Division for Children, Youth, and Families Results ...
Smith, Kristin
core   +1 more source

The Value Driven Pharmacist: Basics of Access, Cost, and Quality 2nd Edition [PDF]

, 2020
https://digitalcommons.butler.edu/butlerbooks/1017/thumbnail ...
Devine, Trish, Jordan, Joseph, Knoderer, Chad, McFarland, Annette, Smith, Carriann, Wilhoite, Jessica   +5 more
core   +1 more source

Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows [PDF]

, 2017
We describe a computational protocol to aid the design of small molecule and peptide drugs that target protein-protein interactions, particularly for anti-cancer therapy. To achieve this goal, we explore multiple strategies, including finding binding hot
A Goncearenco, A Goncearenco, A Marchler-Bauer, A Truszkowski, AA Bogan, B Graves, B Ma, BA Shoemaker, BA Shoemaker, BA Shoemaker, BJ Smith, CA Goble, CM Yates, D Petrey, E Cukuroglu, FP Davis, H Perez-Sanchez, HS Haase, J Bhagat, J Cinatl, JA Wells, K Wolstencroft, M Guharoy, M Li, M Li, M Li, M Petukh, M Tyagi, MK Gilson, MP Mazanetz, N Estrada-Ortiz, P Aloy, P Aloy, P Filippakopoulos, R Mosca, RR Thangudu, S Beisken, S Kim, S Shangary, S Teng, T Rolland, W Yang, WS Valdar, Y Wang, Y Zhao   +44 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Pengaruh Layanan Bimbingan Kelompok terhadap Kesiapan Kembali ke Masyarakat Bagi Warga Binaan Anak Kasus Non Narkoba di Lapas Kelas II B Anak Pekanbaru [PDF]

, 2017
This study aims to determine the effect of group guidance services on the readiness to return to the community for the child assisted children non-drug cases in pekanbaru children\u27s correctional institution.
Arlizon, R. (Raja), Saam, Z. (Zulfaan), Zakri, M. (Muhammad)   +2 more
core  

Public spending for illegal drug and alcohol treatment in hospitals: an EU cross-country comparison [PDF]

, 2014
Background: In view of the current economic crisis and the resulting austerity measures being implemented by governments across Europe, public expenditure for substance abuse treatment has increasingly become a subject of discussion.
Christiaens, Johan, Lievens, Delfine, Vander Laenen, Freya   +2 more
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Situation of Drug Information Centers and Services in Costa Rica

Pharmacy Practice, 2006
PAHO establishes guidelines that must be met by drug information centers (DIC) and the drug information services (DIS). Objective: To describe the operations, activities, and resources of the DICs and the DISs affiliated with public institutions of ...
Hall V, Gomez C, Fernandez-Llimos F
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