Results 61 to 70 of about 2,627,867 (322)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Development and evaluation of a computerised clinical decision support system for switching drugs at the interface between primary and tertiary care

BMC Medical Informatics and Decision Making, 2012
Background Upon admission to a hospital patients’ medications are frequently switched to alternative drugs compiled in so called hospital drug formularies.
Pruszydlo Markus G, Walk-Fritz Stefanie U, Hoppe-Tichy Torsten, Kaltschmidt Jens, Haefeli Walter E   +4 more
doaj   +1 more source

Supporting information for the development of joint local protocols between drug and alcohol partnerships, children and family services. [PDF]

, 2011
The purpose of this document is to support local partnerships to develop joint local protocols between the drug and alcohol partnerships and children and family services.

core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Drug Information Services in Nepal: An Overview, Present Scenario and Future Perspective

Journal of Karnali Academy of Health Sciences, 2022
Introduction Drug Information Centre (DIC) provides services regarding several aspects of drug information, to healthcare professionals and consumers, that are impartial, updated, well-referenced, and critically evaluated.1 This information required ...
Trilochan Panday, Pawan Maharjan, Subodh Dhakal, Prity Dongol, Sharmila Shrestha, Priya Chaudhary, Puja Lama, Ganesh Dangal   +7 more
doaj  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Opinion On Drug Information Services Provided In A Multi- Specialty Teaching Hospital [PDF]

Archives of Pharmacy Practice, 2011
Objective: To evaluate the various drug information queriesreceived, and to access the drug information services providedby the pharmacy practice department.Method: Drug information queries received during wardrounds, direct communication, telephone or ...
T M Vijayakumar, G Poovi, M D Dhanaraju
doaj   +1 more source

Drug information service awareness program and its impact on characteristics of inquiries at DIS unit in Malaysian public hospital

Archives of Pharmacy Practice, 2013
Objectives : To study the Drug Information Service (DIS) awareness program organized by a DIS unit in Malaysian hospital through utilization of provided services by the healthcare professionals, allied healthcare providers, patients and the public, and ...
Aida Azlina Ali, Shafinaz Mohd Yusoff, Suhaidah Mohd Joffry, Mohd Shahezwan Abd Wahab   +3 more
doaj   +1 more source

"It would really support the wider harm reduction agenda across the board": A qualitative study of the potential impacts of drug checking service delivery in Scotland.

PLoS ONE, 2023
Drug checking services (DCS) enable individuals to voluntarily submit a small amount of a substance for analysis, providing information about the content of the substance along with tailored harm reduction support and advice.
Danilo Falzon, Tessa Parkes, Hannah Carver, Wendy Masterton, Bruce Wallace, Vicki Craik, Fiona Measham, Harry Sumnall, Rosalind Gittins, Carole Hunter, Kira Watson, John D Mooney, Elizabeth V Aston   +12 more
doaj   +1 more source