Results 211 to 220 of about 1,087,510 (314)

Assessing Cytochrome P450 Drug Interaction Risk for Dordaviprone Using Physiologically Based Pharmacokinetic Modeling. [PDF]

CPT Pharmacometrics Syst Pharmacol
Jaiswal S, Patel NK, Jones HM, McFeely S, Faison SL, Tippin T, Naderer O.   +6 more
europepmc   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Presence of Drug Interaction Between Penicillin and Hormonal Contraceptives in Women: A Scoping Review. [PDF]

Healthcare (Basel)
Reis-Oliveira J, Cruz AJS, Guimarães NS, Abreu MHNG.   +3 more
europepmc   +1 more source

Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

FEBS Open Bio, EarlyView.
We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Miyuu Saito, Takumi Misaka
wiley   +1 more source

Analysis of adverse events with ruxolitinib using real-world datasets and drug-interaction networks. [PDF]

SAGE Open Med
Tanaka H, Maezawa M, Tanaka M, Umetsu R, Hirofuji S, Miyasaka K, Nakao S, Nokura Y, Yamashita M, Ichihara N, Sugishita K, Yamazaki T, Shiota K, Tamaki H, Iguchi K, Nakamura M.   +15 more
europepmc   +1 more source

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

FEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi, Motohiro Tani   +5 more
wiley   +1 more source

The European Drug-Drug Interaction (EuroDDI) Study Protocol: A Cross-Country Comparison of Drug-Drug Interaction Prevalence in the Older Community-Dwelling Population. [PDF]

Pharmacoepidemiol Drug Saf
Hughes JE, Menditto E, Mucherino S, Orlando V, Moreno-Juste A, Gimeno-Miguel A, Poblador-Plou B, Aza-Pascual-Salcedo M, González-Rubio F, Ioakeim-Skoufa I, Bennett K, Cahir C.   +11 more
europepmc   +1 more source

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source

In Vivo PK-PD and Drug-Drug Interaction Study of Dorzagliatin for the Management of PI3Kα Inhibitor-Induced Hyperglycemia. [PDF]

Pharmaceuticals (Basel)
Jin G, Zheng K, Liu S, Yi H, Wei W, Xu C, Xiang X, Kang Y.   +7 more
europepmc   +1 more source

DRUG INTERACTIONS AND ANAESTHESIA

, 1978
M. D. Rawlins
openalex   +1 more source