Results 341 to 350 of about 11,447,845 (407)
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A Comprehensive Review of Computational Methods For Drug-Drug Interaction Detection
IEEE/ACM Transactions on Computational Biology & Bioinformatics, 2021The detection of drug-drug interactions (DDIs) is a crucial task for drug safety surveillance, which provides effective and safe co-prescriptions of multiple drugs. Since laboratory researches are often complicated, costly and time-consuming, it's urgent
Yang Qiu +4 more
semanticscholar +1 more source
MUFFIN: multi-scale feature fusion for drug-drug interaction prediction
Bioinform., 2021MOTIVATION Adverse drug-drug interactions (DDIs) are crucial for drug research and mainly cause morbidity and mortality. Thus, the identification of potential DDIs is essential for doctors, patients, and the society. Existing traditional machine learning
Yujie Chen +5 more
semanticscholar +1 more source
A multimodal deep learning framework for predicting drug-drug interaction events
Bioinform., 2020MOTIVATION Drug-drug interactions (DDIs) are one of the major concerns in pharmaceutical research. Many machine learning based methods have been proposed for the DDI prediction, but most of them predict whether two drugs interact or not.
Yifan Deng +5 more
semanticscholar +1 more source
Current drug metabolism, 2020
BACKGROUND In January 2020, the US FDA published two final guidelines, one entitled "In vitro Drug Interaction Studies - Cytochrome P450 Enzyme- and Transporter-Mediated Drug Interactions Guidance for Industry" and the other entitled "Clinical Drug ...
Sirimas Sudsakorn +3 more
semanticscholar +1 more source
BACKGROUND In January 2020, the US FDA published two final guidelines, one entitled "In vitro Drug Interaction Studies - Cytochrome P450 Enzyme- and Transporter-Mediated Drug Interactions Guidance for Industry" and the other entitled "Clinical Drug ...
Sirimas Sudsakorn +3 more
semanticscholar +1 more source
Current Opinion in Anaesthesiology, 2001
The prevalence of undesirable drug interactions is substantial but largely unknown. Although drug interactions are certainly an important cause of drug toxicity, their clinical significance may have been exaggerated. This review presents a brief overview of possible drug interactions.
K T, Olkkola, J, Ahonen
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The prevalence of undesirable drug interactions is substantial but largely unknown. Although drug interactions are certainly an important cause of drug toxicity, their clinical significance may have been exaggerated. This review presents a brief overview of possible drug interactions.
K T, Olkkola, J, Ahonen
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Drug Metabolism Reviews, 2009
Drugs for allergy are often taken in combination with other drugs, either to treat allergy or other conditions. In common with many pharmaceuticals, most such drugs are subject to metabolism by P450 enzymes and to transmembrane transport. This gives rise to considerable potential for drug-drug interactions, to which must be added consideration of drug ...
Alan, Boobis +5 more
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Drugs for allergy are often taken in combination with other drugs, either to treat allergy or other conditions. In common with many pharmaceuticals, most such drugs are subject to metabolism by P450 enzymes and to transmembrane transport. This gives rise to considerable potential for drug-drug interactions, to which must be added consideration of drug ...
Alan, Boobis +5 more
openaire +2 more sources
Clinics in Podiatric Medicine and Surgery, 1992
Drug-drug interactions are most likely to occur in patients receiving multiple medications and with drugs that have a narrow therapeutic window. The outcome may be harmful or beneficial, but the relative incidence of clinically important adverse drug interactions remains unknown.
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Drug-drug interactions are most likely to occur in patients receiving multiple medications and with drugs that have a narrow therapeutic window. The outcome may be harmful or beneficial, but the relative incidence of clinically important adverse drug interactions remains unknown.
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Veterinary Clinics of North America: Small Animal Practice, 1988
Drug interactions are often the result of complex biochemical, physical, and kinetic factors and may not often be easily predicted or even recognized. Although this article has attempted to point out the more common mechanisms and results of drug interactions, the few interactions that have been documented in small animals are undoubtedly only the tip ...
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Drug interactions are often the result of complex biochemical, physical, and kinetic factors and may not often be easily predicted or even recognized. Although this article has attempted to point out the more common mechanisms and results of drug interactions, the few interactions that have been documented in small animals are undoubtedly only the tip ...
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CARDIOVASCULAR DRUG-DRUG INTERACTIONS
Cardiology Clinics, 2001The drug-drug interactions discussed in this article have either documented or suspected clinical relevance for patients with cardiovascular disease and the clinician involved in the care of these patients. Oftentimes, drug-drug interactions are difficult, if not impossible, to predict because of the high degree of interpatient variability in drug ...
J R, Anderson, J J, Nawarskas
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Perioperative drug interactions
Journal of Clinical Anesthesia, 1993The various classes of IV and inhalation anesthetics all appear to potentiate one another. Many of these interactions are clinically useful in outpatient anesthesia, and many are quite predictable. True synergy is most likely to occur when two drugs produce similar actions by slightly different mechanisms.
P, Michalowski, C E, Rosow
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