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Matrix Approach Assessment of Cabotegravir Drug-Drug Interactions with OAT1/OAT3 Substrates and UGT1A1/UGT1A9 Inhibitors Using Physiologically-Based Pharmacokinetic Modeling. [PDF]
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An updated review of pharmacokinetic drug interactions and pharmacogenetics of statins
Expert Opinion on Drug Metabolism & Toxicology, 2020Introduction Hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) lower cholesterol synthesis in patients with hypercholesterolemia. Increased statin exposure is an important risk factor for skeletal muscle toxicity.
Takeshi Hirota, Yuito Fujita, I. Ieiri
semanticscholar +1 more source
Clinical Aspects of Transporter‐Mediated Drug–Drug Interactions
Clinical pharmacology and therapy, 2019Drug transporters play an essential role in disposition and effects of multiple drugs. Plasma concentrations of the victim drug can be modified by drug–drug interactions occurring in enterocytes (e.g., P‐glycoprotein), hepatocytes (e.g., organic anion ...
A. Gessner, J. König, M. Fromm
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Drug–drug interaction with statins
Expert Review of Clinical Pharmacology, 20083-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase inhibitors (the so-called statins: atorvastatin, fluvastatin, pravastatin, lovastatin, rosuvastatin and simvastatin) are a well-established class of drugs in the treatment of hypercholesterolemia. Statin monotherapy is generally well tolerated, with a low frequency of adverse events.
A. Corsini, S. Bellosta
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A drug-to-drug interaction package
Computer Methods and Programs in Biomedicine, 1989This paper describes an electronic database for handling the interactions between active principles administered to various patients. The computer used is a personal computer with adequate mass memory, software, and data obtained from pharmacological sources.
PINCIROLI, FRANCESCO, POZZI, GIUSEPPE
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Statin drug interactions and related adverse reactions: an update
Expert Opinion on Drug Safety, 2018Introduction: Statins reduce the risk of cardiovascular morbidity and mortality in patients with or at risk for cardiovascular disease and their use is expanding, especially in elderly.
S. Bellosta, A. Corsini
semanticscholar +1 more source
Herb-Drug Interactions and Hepatotoxicity.
Current drug metabolism, 2019BACKGROUND In recent times, herbals or phytomedicines have become very popular due to their global acceptance as a complementary and alternative remedy. While modern drugs are commercially available only after laboratory validations, clinical trials, as ...
M. Parvez, V. Rishi
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Drug Metabolism Reviews, 2009
Drugs for allergy are often taken in combination with other drugs, either to treat allergy or other conditions. In common with many pharmaceuticals, most such drugs are subject to metabolism by P450 enzymes and to transmembrane transport. This gives rise to considerable potential for drug-drug interactions, to which must be added consideration of drug ...
Alan, Boobis +5 more
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Drugs for allergy are often taken in combination with other drugs, either to treat allergy or other conditions. In common with many pharmaceuticals, most such drugs are subject to metabolism by P450 enzymes and to transmembrane transport. This gives rise to considerable potential for drug-drug interactions, to which must be added consideration of drug ...
Alan, Boobis +5 more
openaire +2 more sources
Current Opinion in Anaesthesiology, 2001
The prevalence of undesirable drug interactions is substantial but largely unknown. Although drug interactions are certainly an important cause of drug toxicity, their clinical significance may have been exaggerated. This review presents a brief overview of possible drug interactions.
K T, Olkkola, J, Ahonen
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The prevalence of undesirable drug interactions is substantial but largely unknown. Although drug interactions are certainly an important cause of drug toxicity, their clinical significance may have been exaggerated. This review presents a brief overview of possible drug interactions.
K T, Olkkola, J, Ahonen
openaire +2 more sources