Results 221 to 230 of about 9,974,913 (281)

SSI-DDI: substructure-substructure interactions for drug-drug interaction prediction

Briefings Bioinform., 2021
A major concern with co-administration of different drugs is the high risk of interference between their mechanisms of action, known as adverse drug-drug interactions (DDIs), which can cause serious injuries to the organism.
Arnold K. Nyamabo, Hui Yu, Jian-Yu Shi
semanticscholar   +1 more source

Rivaroxaban - Metabolism, Pharmacologic Properties and Drug Interactions.

Current drug metabolism, 2017
BACKGROUND Rivaroxaban represents a selective direct inhibitor of activated coagulation factor X (FXa) having peroral bioavailability and prompt onset of action.
T. Kvasnička, I. Malíková, Z. Zenáhlíková, Karolína Kettnerová, R. Brzežková, T. Zima, J. Ulrych, J. Bříza, I. Netuka, J. Kvasnička   +9 more
semanticscholar   +1 more source

Pharmacokinetic properties and drug interactions of apigenin, a natural flavone

Expert Opinion on Drug Metabolism & Toxicology, 2017
Introduction: Apigenin, a natural flavone, is widely distributed in plants such as celery, parsley and chamomile. It is present principally as glycosylated in nature. Higher intake of apigenin could reduce the risk of chronic diseases.
Dingning Tang, Ke-Li Chen, Luqi Huang, Juan Li   +3 more
semanticscholar   +1 more source

Assessing drug-drug interactions through therapeutic drug monitoring when administering oral second-generation antipsychotics

Expert Opinion on Drug Metabolism & Toxicology, 2016
Introduction: Second-generation antipsychotics (SGAs) are frequently co-prescribed with drug metabolic inducers and inhibitors. SGA pharmacokinetic drug-drug interactions (DDIs) with inducers and inhibitors have not received enough attention in the ...
E. Spina, C. Hiemke, J. de Leon
semanticscholar   +1 more source

Curcumin as a clinically-promising anti-cancer agent: pharmacokinetics and drug interactions

Expert Opinion on Drug Metabolism & Toxicology, 2017
Introduction: Curcumin has been extensively studied for its anti-cancer properties. While a diverse array of in vitro and preclinical research support the prospect of curcumin use as an anti-cancer therapeutic, most human studies have failed to meet the ...
Jeffry Adiwidjaja, A. McLachlan, A. Boddy   +2 more
semanticscholar   +1 more source

DRUG INTERACTIONS

Clinics in Podiatric Medicine and Surgery, 1992
Drug-drug interactions are most likely to occur in patients receiving multiple medications and with drugs that have a narrow therapeutic window. The outcome may be harmful or beneficial, but the relative incidence of clinically important adverse drug interactions remains unknown.
openaire   +2 more sources

Drug Interactions

Veterinary Clinics of North America: Small Animal Practice, 1988
Drug interactions are often the result of complex biochemical, physical, and kinetic factors and may not often be easily predicted or even recognized. Although this article has attempted to point out the more common mechanisms and results of drug interactions, the few interactions that have been documented in small animals are undoubtedly only the tip ...
openaire   +2 more sources

Drug—Drug Interactions in the Elderly

Annals of Pharmacotherapy, 2002
OBJECTIVE: To detect the frequency of potential drug—drug interactions (DDIs) in an outpatient group of elderly people in 6 European countries, as well as to describe differences among countries. DATA SOURCES AND METHODS: Drug use data were collected from 1601 elderly persons living in 6 European countries.
Ingeborg K Björkman, Johan Fastbom, Ingrid K Schmidt, Cecilia B Bernsten, Cecilia B Bernsten, Ingeborg K Björkman, Margarida Caramona, Grainne Crealey, Bente Frøkjær, Erika Grünberger, Tove Gustafsson, Martin Henman, Hanne Herborg, Carmel Hughes, James C McElnay, Maeve Magner, Foppe van Mil, Marion Schaeffer, Sonia Silva, Birthe Søndergaard, Ian Sturgess, Dick Tromp, Lisa Vivero, Almut Winterstein   +23 more
openaire   +3 more sources

Drug–drug interactions and safety of linezolid, tedizolid, and other oxazolidinones

Expert Opinion on Drug Metabolism & Toxicology, 2015
Introduction: Oxazolidinones are synthetic antimicrobials with strong bacteriostatic activity against Gram-positive organisms. Recently, tedizolid phosphate was approved for clinical use becoming the second agent of this class after linezolid available ...
A. Douros, Katja Grabowski, R. Stahlmann
semanticscholar   +1 more source

CARDIOVASCULAR DRUG-DRUG INTERACTIONS

Cardiology Clinics, 2001
The drug-drug interactions discussed in this article have either documented or suspected clinical relevance for patients with cardiovascular disease and the clinician involved in the care of these patients. Oftentimes, drug-drug interactions are difficult, if not impossible, to predict because of the high degree of interpatient variability in drug ...
James J. Nawarskas, Joe R. Anderson
openaire   +3 more sources