The impact of CYP2C19 genotype on phenoconversion by concomitant medication
Frontiers in Pharmacology, 2023 Introduction: Pharmacogenetics-informed drug prescribing is increasingly applied in clinical practice. Typically, drug metabolizing phenotypes are determined based on genetic test results, whereupon dosage or drugs are adjusted.
Laura M. de Jong +11 more
doaj +1 more source
Evaluation of potential drug-drug interactions in medical wards of a referral university hospital in southern part of Iran: a retrospective observational study [PDF]
Trends in Pharmaceutical Sciences, 2021 Introduction: Drug-drug interactions impose several financial and medical burden on medical system and can lead to various health problems. The aim of this study was to investigate the incidence of Potential Drug-Drug Interactions (PDDIs) and its related
Farzaneh Foroughinia +2 more
doaj +1 more source
Pharmacodynamic Drug–Drug Interactions
Clinical pharmacology and therapy, 2019 Pharmacodynamic drug–drug interactions (DDIs) occur when the pharmacological effect of one drug is altered by that of another drug in a combination regimen. DDIs often are classified as synergistic, additive, or antagonistic in nature, albeit these terms
Jin Niu, R. Straubinger, D. Mager
semanticscholar +1 more source
AMFPMC -- An improved method of detecting multiple types of drug-drug interactions using only known drug-drug interactions [PDF]
arXiv, 2023 Adverse drug interactions are largely preventable causes of medical accidents, which frequently result in physician and emergency room encounters. The detection of drug interactions in a lab, prior to a drug's use in medical practice, is essential, however it is costly and time-consuming.
arxiv
Potential drug-drug interactions and prescription errors in COVID-19 infected patients
Public Health and Toxicology, 2023 Introduction Prescription errors can cause havoc during the pandemic, especially for comorbid patients with diabetes and hypertension identified as a risky population group for COVID-19.
Syeda R. Tasfia +6 more
doaj +1 more source
Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. [PDF]
, 2020 Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alhaja, Maher +8 more
core +1 more source
Medicinal Cannabis—Potential Drug Interactions
Medicines, 2018 The endocannabinoids system (ECS) has garnered considerable interest as a potential therapeutic target in various carcinomas and cancer-related conditions alongside neurodegenerative diseases.
Muhammad A. Alsherbiny +2 more
semanticscholar +1 more source
Data-driven prediction of adverse drug reactions induced by drug-drug interactions
BMC Pharmacology and Toxicology, 2017 Background The expanded use of multiple drugs has increased the occurrence of adverse drug reactions (ADRs) induced by drug-drug interactions (DDIs). However, such reactions are typically not observed in clinical drug-development studies because most of ...
Ruifeng Liu +5 more
doaj +1 more source
NeuroCADR: Drug Repurposing to Reveal Novel Anti-Epileptic Drug Candidates Through an Integrated Computational Approach [PDF]
arXiv, 2023 Drug repurposing is an emerging approach for drug discovery involving the reassignment of existing drugs for novel purposes. An alternative to the traditional de novo process of drug development, repurposed drugs are faster, cheaper, and less failure prone than drugs developed from traditional methods.
arxiv
Herbal - Synthetic Drug Interactions
Magna Medika, 2023 Background: Herbal medicine is currently one of the therapeutic options chosen by the community because it is considered relatively safer and has minimal side effects.
Kintoko Kintoko +7 more
doaj +1 more source