Results 151 to 160 of about 471,442 (349)
Establishment and biological characterization of radioresistant colorectal cancer cell lines
FEBS Open Bio, EarlyView.Under ionizing radiation exposure, radiation‐sensitive cancer cells exhibit oxidative stress and DNA damage, while radiation‐resistant cancer cells exhibit strong antioxidant properties and DNA damage repair. Radiotherapy resistance is a major cause of recurrence and metastasis in colorectal cancer (CRC).
Tian‐Yin Qu +10 more
wiley +1 more source
Exploratory Research in Clinical and Social Pharmacy, 2023 Background: Caregivers often have difficulty administering pediatric medications which frequently results in increased dosing error risk. Objective: We examined health literacy characteristics of pediatric over-the-counter (OTC) oral suspension ...
Alexis M. Loehfelm +2 more
doaj
DrugCLIP: Contrastive Drug-Disease Interaction For Drug Repurposing [PDF]
arXivBringing a novel drug from the original idea to market typically requires more than ten years and billions of dollars. To alleviate the heavy burden, a natural idea is to reuse the approved drug to treat new diseases. The process is also known as drug repurposing or drug repositioning.
arxiv
Relationship between systemic drug absorption and gastrointestinal transit after the simultaneous oral administration of carbamazepine as a controlled‐release system and as a suspension of 15N‐labelled drug to healthy volunteers. [PDF]
, 1991 IR Wilding +8 more
openalex +1 more source
FEBS Open Bio, EarlyView.Measuring AMP‐activated protein kinase (AMPK) activity in vitro is crucial for testing AMPK activators or inhibitors with therapeutic potential. Here, we report an enzyme‐linked immunosorbent assay (ELISA)‐based AMPK activity assay with simple steps and high sensitivity, which offers a simple, robust, and cost‐effective alternative to traditional ...
Trezze P. Nguyen, Shangze Lyu, Yang Liu
wiley +1 more source
GENN: Predicting Correlated Drug-drug Interactions with Graph Energy Neural Networks [PDF]
arXiv, 2019 Gaining more comprehensive knowledge about drug-drug interactions (DDIs) is one of the most important tasks in drug development and medical practice. Recently graph neural networks have achieved great success in this task by modeling drugs as nodes and drug-drug interactions as links and casting DDI predictions as link prediction problems.
arxiv
Animal drug container labels: A guide to the reader [PDF]
, 1993 Andrew I. Webb, Gina Aeschbacher
openalex +1 more source
FEBS Open Bio, EarlyView.We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang +9 more
wiley +1 more source
Affinity‐Directed Site‐Specific Protein Labeling and Its Application to Antibody‐Drug Conjugates
Advanced ScienceChemically modified proteins have diverse applications; however, conventional chemo‐selective methods often yield heterogeneously labeled products. To address this limitation, site‐specific protein labeling holds significant potential, driving extensive ...
Sooin Kim +9 more
doaj +1 more source