Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett +8 more
wiley +1 more source
Paediatric cardiovascular clinical trials: an analysis of ClinicalTrials.gov and the Food and Drug Administration Pediatric Drug Labeling Database. [PDF]
Cardiol Young, 2015 Hill KD, Henderson HT, Hornik CP, Li JS.
europepmc +1 more source
Brief of Amici Curiae Former FDA Commissioners Dr. Donald Kennedy and Dr. David A. Kessler in Support of Respondent, Wyeth v. Levine, No. 06-1249 (U.S. Aug. 14, 2008) [PDF]
, 2008 Sabbeth, Kathryn A., Vladeck, David C.
core +1 more source
The Use of Stable Isotope-Labeled Drug as Microtracers with Conventional LC–MS/MS to Support Human Absolute Bioavailability Studies: are We There Yet? [PDF]
, 2016 Shuguang Ma, Swapan K. Chowdhury
openalex +1 more source
Arthritis Care &Research, EarlyView.Objective This study examined the global and regional temporal changes in cross‐country inequalities of site‐specific osteoarthritis (OA) burden from 1990 to 2021. Methods Age‐standardized years lived with disability rates (ASYRs) for site‐specific OA across 204 countries and territories were obtained from the Global Burden of Diseases, Injuries, and ...
Haowei Chen +14 more
wiley +1 more source
The Major Role of Clinicians in the Discovery of Off-Label Drug Therapies
, 2005 Harold J. DeMonaco +2 more
openalex +1 more source
Efficacy of Off-Label Use of Anticancer Drugs in Oncology
, 2023 Е. В. Карабина +2 more
openalex +2 more sources
Arthritis Care &Research, EarlyView.Objective Although treat‐to‐target urate‐lowering therapy (ULT) is endorsed as best practice in gout management, limited data exist on its impact on health‐related quality of life (HRQoL). We assessed the impact of treat‐to‐target ULT on HRQoL among participants receiving protocolized gout care, identifying factors associated with HRQoL and HRQoL ...
Austin Barry +16 more
wiley +1 more source
The Federal Food Legislation of 1938 and the Food Industry [PDF]
, 1939 Austin, Robert W.
core +2 more sources