Results 261 to 270 of about 471,442 (349)

Improving drug repositioning with negative data labeling using large language models. [PDF]

open access: yesJ Cheminform
Picard M   +5 more
europepmc   +1 more source

Covalent On‐Cell Conjugation of Biomaterials Through Oxidative Phenolic Coupling Regulates Stem Cell Fate via Intracellular Biophysical Programming

open access: yesAdvanced Functional Materials, EarlyView.
On‐cell covalent crosslinking of hydrogel matrix to the membrane of a single cell using droplet microfluidics enables mechanotransduction and influences stem cell fate. This newly established approach influences stem cell fate, independent of YAP/TAZ mechanotransduction and non‐covalent reversible binding ligands yet by various intracellular ...
Castro Johnbosco   +6 more
wiley   +1 more source

3D In Vitro Glioma‐Neuron‐Astrocyte Biomimetic Composites Recapitulate Key Molecular Mechanisms Linked to Glioblastoma Multiforme Pathophysiology

open access: yesAdvanced Functional Materials, EarlyView.
Glioblastoma multiforme is the most devastating and incurable brain tumor. To better study this disease, a 3D model is developed using a hyaluronic acid‐based hydrogel combined with a multicellular approach. This model recapitulates in vivo brain stiffness, cell‐extracellular matrix and cell‐cell interactions and the tumor's hijacking function with the
Mateo S. Andrade Mier   +26 more
wiley   +1 more source

Impact of pharmacometrics on drug approval and labeling decisions: A survey of 42 new drug applications

open access: green, 2005
Venkatesh Atul Bhattaram   +14 more
openalex   +2 more sources

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