Results 121 to 130 of about 29,922 (309)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Breaking Barriers: Nanomedicine-Based Drug Delivery for Cataract Treatment
International Journal of NanomedicineYilin Chen,1,2 Zi Ye,1,2 Haixu Chen,3 Zhaohui Li1,2 1School of Medicine, Nankai University, Tianjin, People’s Republic of China; 2Senior Department of Ophthalmology, The Chinese People’s Liberation Army General Hospital, Beijing, People’s Republic of ...
Chen Y, Ye Z, Chen H, Li Z
doaj
International Journal of Nanomedicine, 2015 Wei Wang,1,* Mei Xi,2,* Xuezhong Duan,1 Yong Wang,3 Fansheng Kong4 1Department of Chinese Medicine Integrated Traditional Chinese Medicine and Western Medicine, General Hospital of Ji’nan Command, People’s Liberation Army, 2Emergency ...
Wang W, Xi M, Duan X, Wang Y, Kong F
doaj
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
, 2019 In order to quantitatively account of tegafur drug interaction with graphene oxide nanosheet, various geometrical structures are examined to study the detailed effects of drug adsorption on the structural properties, interaction energy and charge ...
Mahnaz Shahabi (4381372) +1 more
core +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Critical processes in drug release from HPMC controlled release matrices [PDF]
, 2009 This study has investigated the drug release mechanisms from hydroxypropyl methylcellulose (HPMC) hydrophilic matrices. A hypothesis was developed from interpretation of a previous study that drug surface activity has an influence on drug liberation. The
Pygall, Samuel R, Pygall, Samuel R.
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Logic and Limits of Animal Liberation
, 1984 The current interest in treatment towards animals goes beyond the focus of isolated instances of brutality and encompasses the advocacy of significant changes in our traditional attitudes toward animals. In one year (1980) an estimated 2,054,281,000 hogs,
Bennett, Edward R.
core