Results 131 to 140 of about 29,922 (309)
Multi-omics analysis of kidney renal cell carcinoma in silico with preliminary in vivo validation
Frontiers in ImmunologyBackgroundKidney renal clear cell carcinoma (KIRC) has a poor clinical prognosis, and its tumor progression and immunotherapy response are closely associated with genomic aberrations and immune microenvironment disorders. This study aimed to identify key
Tingyu Su +12 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Physicochemical Properties and Release Profiles of Lidocaine Hydrochloride in Microemulsion Gels
European Pharmaceutical JournalThis study focuses on the development and characterization of microemulsion gel systems incorporating the model drug lidocaine. Microemulsions were prepared via the standard phase titration method using various oil phases, surfactants, and co-surfactants,
Jackuliaková Patrícia +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
A MULTIPURPOSE AND NOVEL CARRIER FOR DRUG DELIVERY AND TARGETING - VIROSOMES
, 2013 There is presently passionate investigation bustle aimed at the improvement of new delivery systems for vaccines. The aspiration is to identify best possible methods for presenting target antigens to the immune system in a manner that will elicit immune ...
Patel, M, Lad, C, Vyas, R B, Kapoor, D
core +1 more source
Infection and Drug ResistanceYixin Kang,1,2 Suhai Kang,3 Junchang Cui1 1College of Pulmonary and Critical Care Medicine, Chinese People’s Liberation Army General Hospital, Beijing, People’s Republic of China; 2School of Medicine, Nankai University, Tianjin, People’s Republic of ...
Kang Y, Kang S, Cui J
doaj
Frontiers in Bioengineering and BiotechnologySpinal cord injury (SCI) is a pathological condition that damages the central nervous system. Due to the persistence of neuroinflammation after injury, the prognosis is often poor.
Wenshui Li +17 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Qualitative findings from North America's first drug compassion club.
In Canada, the ongoing fatal overdose crisis remains driven by the unpredictable potency and content of the illicit drug supply. From August 2022 until October 2023, the Drug User Liberation Front [DULF] operated a drug compassion club [CC], which sells ...
Jeremy Kalicum +3 more
core +1 more source