Results 191 to 200 of about 1,874,942 (252)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

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Economics of drug liberalization

2005
This highly innovative and intriguing book applies principles of microeconomics to unusual settings to inspire students, teachers and scholars alike in the ‘dismal science'. Leading experts show how economics reaches into the strangest of places and throws light onto the occasionally dark side of human nature.
Mark Thornton, Bruce L. Benson, Simon W. Bowmaker   +2 more
openaire   +1 more source

Liberal Neutrality, Autonomy, and Drug Prohibitions

Philosophy & Public Affairs, 2000
Face a l'importance du taux d'incarceration aux Etats-Unis, l'A. defend, parmi les theories liberales, celle de la neutralite qui revendique la protection de l'autonomie de la personne contre l'emprisonnement systematique issu du droit penal, d'une part, et lutte contre la criminalisation de l'usage leger de la drogue, d'autre part.
openaire   +1 more source

Prohibition or Liberalization of Alcohol and Drugs?

1992
The “war against drugs,” and calls for increasing restrictions on the availability of alcoholic beverages, reflect a resurgence in the popularity of mandated formal controls and suspicion of informal controls. A small, but increasing countercurrent recommends various forms of liberalization of access to alcohol and drugs.
openaire   +1 more source

Liberalization and integration of drug distribution in the EU 28 and Norway

Česká a slovenská farmacie, 2018
The pharmaceutical distribution system in Europe is undergoing a long-term change. Wholesale companies join together to form both horizontally and vertically integrated structures. Pharmacies, formerly owned almost exclusively by pharmacists, are becoming part of the chain thanks to the liberalization of operating conditions.
Jaroslav, Písek, Kamil, Pícha
openaire   +2 more sources

A history of drugs: Drugs and freedom in the liberal age, by Toby Seddon

Drugs: Education, Prevention and Policy, 2010
In A History of Drugs: Drugs and Freedom in the Liberal Age, Toby Seddon makes a bold attempt to rethink drug policy in the present by examining its past.
openaire   +1 more source

Danish drug policy—shifting from liberalism to repression

Drugs and Alcohol Today, 2008
In the course of the 2000s Denmark has experienced a shift in drug policy in general and of cannabis policy in particular. Danish drug policy used to be known as liberal, but is now saturated with ‘zero‐tolerance’ and ‘tough on crimes’ rhetoric. What happened, and what have the consequences been?
openaire   +2 more sources