Results 121 to 130 of about 12,013,030 (353)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

The Dilemma of Treating Delirium: the Conundrum of Drug Management. [PDF]

Curr Treat Options Oncol, 2022
Agar MR, Amgarth-Duff I.
europepmc   +1 more source

Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Regimen [PDF]

, 2023
AVANI JOSHI -, KALPITA THAKKAR -, VIVEK JETANI -, SACHIN BHATT -, USHA SHINDE -   +4 more
openalex   +1 more source

Managing drug addicts [PDF]

British Dental Journal, 2016
openaire   +2 more sources

Persistence with topical glaucoma therapy in Japan from the perspective of product, formulation, and patient characteristics: analysis of medical insurance claim data

BMC Ophthalmology
Background Glaucoma is the leading cause of irreversible blindness in Japan and constitutes a serious public health challenge. Due to its asymptomatic onset and slow progression, patient persistence with topical glaucoma therapies remains low ...
Kenji Kabeya, Hiroki Satoh, Natsuyo Yanagi, Yasufumi Sawada   +3 more
doaj   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

Multiplexed biosensor for point-of-care COVID-19 monitoring: CRISPR-powered unamplified RNA diagnostics and protein-based therapeutic drug management. [PDF]

Mater Today (Kidlington), 2022
Johnston M, Ceren Ates H, Glatz RT, Mohsenin H, Schmachtenberg R, Göppert N, Huzly D, Urban GA, Weber W, Dincer C.   +9 more
europepmc   +2 more sources

Bisphosphonate compliance in Japan from the perspective of product, formulation, and patient characteristics: analysis of medical insurance claim data

Journal of Pharmaceutical Health Care and Sciences
Background Bisphosphonates are the mainstay drugs for osteoporosis, but in clinical practice, they are often ineffective due to low compliance. However, there have been few studies examining compliance on a product-by-product basis or in detail in Japan.
Kenji Kabeya, Hiroki Satoh, Natsuyo Yanagi, Yasufumi Sawada   +3 more
doaj   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source