Results 141 to 150 of about 23,893,303 (352)

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Repository Strategic Management Business Journal

Strategic Management Business Journal is a forum for researchers in management science, especially in creating the effect of improving organizational performance in human resource management, financial management, and marketing management.
journal, strategic management business
core   +1 more source

Alcohol and other drug treatment services in Australia 2011-12 [PDF]

, 2013
This report presents information on treatment episodes provided by publicly funded treatment services for alcohol and other drug use.SummaryPublicly funded alcohol and other drug treatment services are available to people seeking treatment for their own

core  

Toxicological Impacts of Polypropylene Nanoparticles Similar in Size to Nanoplastics in Plastic-Bottle Injections on Human Umbilical Vein Endothelial Cells

Toxics
Microplastic and nanoplastic (MNP) particles have been observed in various human organs. However, polypropylene (PP), one of the top three most commonly detected types of MNPs in terms of quantity, is also present in injections given for the infusion ...
Jie Wang, Zhong-Lan Chen, Cheng-Gang Liang, Hui-Ying Yang, Xian-Fu Wu, Hui-Min Sun   +5 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Injectable drugs for weight management

Australian Prescriber
Obesity management is complex; medications must be used in conjunction with behavioural changes and monitoring by health professionals. Injectable drugs for weight management include glucagon-like peptide-1 (GLP-1) receptor agonists (e.g. liraglutide, semaglutide) and dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonists (e.g.
Natasha Yates, Terri-Lynne South
openaire   +3 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Drug-related and drug-misuse deaths 2008-2018.

, 2020
There were 189 drug-related deaths registered in Northern Ireland in 2018. Half (95) of these deaths were of men aged 25-44. These are some of the findings of the statistics published today by the Northern Ireland Statistics and Research Agency (NISRA).

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Persistence with topical glaucoma therapy in Japan from the perspective of product, formulation, and patient characteristics: analysis of medical insurance claim data

BMC Ophthalmology
Background Glaucoma is the leading cause of irreversible blindness in Japan and constitutes a serious public health challenge. Due to its asymptomatic onset and slow progression, patient persistence with topical glaucoma therapies remains low ...
Kenji Kabeya, Hiroki Satoh, Natsuyo Yanagi, Yasufumi Sawada   +3 more
doaj   +1 more source

Managing drug addicts [PDF]

British Dental Journal, 2016
openaire   +2 more sources