Results 1 to 10 of about 805,576 (247)

Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis

open access: yesRedox Biology, 2021
Hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) is a ferroptotic cell death signal. HpETE-PE is produced by the 15-Lipoxygenase (15LOX)/Phosphatidylethanolamine Binding Protein-1 (PEBP1) complex or via an Fe-catalyzed non-enzymatic ...
Tamil S. Anthonymuthu   +15 more
doaj   +1 more source

Prooxidant and antioxidant processes in the liver homogenate of healthy and tumor-bearing mice under the action of thiazole derivatives [PDF]

open access: yesThe Ukrainian Biochemical Journal, 2021
Thiazole derivatives were shown to have toxic effects in vitro on cancer cells of different origin and can be considered as potentially antineoplastic, but their effect on the normal tissues needs to be studied.
Ya. R. Shalai   +5 more
doaj   +1 more source

Free radical processes in rat liver in experimental diabetes, malignant growth and their combination

open access: yesИсследования и практика в медицине, 2022
Purpose of the study. To study the intensity of lipid peroxidation (LPO) and indicators of antioxidant protection in the liver of rats of different sexes with combined pathology – the growth of Guerin's carcinoma in presence of experimental type 1 ...
I. A. Goroshinskaya   +9 more
doaj   +1 more source

EXPERIMENTAL PARTICIPATION OF PHARMACOLOGICAL SUBSTANCES IN MECHANISMS OF LEAD ACETATE TOXICITY

open access: yesФармация и фармакология (Пятигорск), 2023
The aim of the work is to study pharmacological substances that play a role of eNOS expression regulators in the modification of lead intoxication effects in the experiment.Materials and methods.
S. G. Dzugkoev   +4 more
doaj   +1 more source

Versatile roles of polyamines in improving abiotic stress tolerance of plants

open access: yesFrontiers in Plant Science, 2022
In recent years, extreme environmental cues such as abiotic stresses, including frequent droughts with irregular precipitation, salinity, metal contamination, and temperature fluctuations, have been escalating the damage to plants’ optimal productivity ...
Jinhua Shao   +19 more
doaj   +1 more source

Low-level cadmium exposure induced hormesis in peppermint young plant by constantly activating antioxidant activity based on physiological and transcriptomic analyses

open access: yesFrontiers in Plant Science, 2023
As one of the most toxic environmental pollutants, cadmium (Cd) has lastingly been considered to have negative influences on plant growth and productivity. Recently, increasing studies have shown that low level of Cd exposure could induce hormetic effect
Bin Wang   +18 more
doaj   +1 more source

The role of oil solutions of thiosulfonates in the modulation of antioxidant parameters in rat kidneys

open access: yesБіологія тварин, 2023
This study investigated the influence of thiosulfonate esters, specifically S-ethyl-4-aminobenzenethiosulfonate (ETS), S-allyl-4-aminobenzenethiosulfonate (ATS), and S-allyl-4-acetylaminobenzenethiosulfonate (AATS), at a dose of 50 mg/kg body weight on ...
N. M. Liubas, I. Ya. Oliynyk
doaj   +1 more source

NF-κB/HDAC1/SREBP1c pathway mediates the inflammation signal in progression of hepatic steatosis

open access: yesActa Pharmaceutica Sinica B, 2020
The transcription factor nuclear factor kappa B (NF-κB) is activated in hepatocytes in the pathogenesis of hepatic steatosis. However, the action mechanism of NF-κB remains to be established in the hepatic steatosis.
Yunwei Guo   +7 more
doaj   +1 more source

COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment

open access: yesAntioxidants, 2022
COVID-19 has reached pandemic proportions worldwide, with considerable consequences for both health and the economy. In pregnant women, COVID-19 can alter the metabolic environment, iron metabolism, and oxygen supply of trophoblastic cells, and therefore
Jorge Moreno-Fernandez   +12 more
doaj   +1 more source

Dynamic Responses of Antioxidant and Glyoxalase Systems to Seed Aging Based on Full-Length Transcriptome in Oat (Avena sativa L.)

open access: yesAntioxidants, 2022
Seed aging is a major challenge for food security, agronomic production, and germplasm conservation, and reactive oxygen species (ROS) and methylglyoxal (MG) are highly involved in the aging process.
Ming Sun   +10 more
doaj   +1 more source

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