Results 151 to 160 of about 23,893,303 (352)
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Drug-related and drug-misuse deaths 2009-2019.
, 2021 There were 191 drug-related deaths registered in Northern Ireland in 2019. Almost half (45.5%) of these deaths were of men aged 25-44. These are some of the findings of the statistics published today by the Northern Ireland Statistics and Research Agency
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Instillation success rates among glaucoma eyedrop products: patient survey in Japan
BMC OphthalmologyBackground Glaucoma is the leading cause of blindness in Japan and poses a significant public health challenge. Previous studies have reported low success rates for antiglaucoma eyedrop instillation.
Kenji Kabeya +3 more
doaj +1 more source
Development of a Drug Management Performance Application: A Needs Assessment in Indonesia. [PDF]
Healthc Inform Res, 2023 Faradiba, Satibi, Lazuardi L.
europepmc +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Journal of Pharmaceutical Health Care and SciencesBackground Bisphosphonates are the mainstay drugs for osteoporosis, but in clinical practice, they are often ineffective due to low compliance. However, there have been few studies examining compliance on a product-by-product basis or in detail in Japan.
Kenji Kabeya +3 more
doaj +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Policing alcohol and illicit drug use among Aboriginal and Torres Strait Islander people in metropolitan environments [PDF]
, 2014 Executive summary: This report presents the results of Australian Institute of Criminology research on issues and challenges of policing alcohol and illicit drug use among Aboriginal and Torres Strait Islander people in metropolitan environments.
David Marks, Jason Payne, Tracy Cussen
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Drug management of autosomal dominant polycystic kidney disease. [PDF]
Aust Prescr, 2022 Theivendran T, Ramachandran A, Rangan G.
europepmc +1 more source
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source