Results 121 to 130 of about 23,893,303 (352)
Targeted protein degradation: advances in drug discovery and clinical practice
Signal Transduction and Targeted TherapyTargeted protein degradation (TPD) represents a revolutionary therapeutic strategy in disease management, providing a stark contrast to traditional therapeutic approaches like small molecule inhibitors that primarily focus on inhibiting protein function.
Guangcai Zhong +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Drug Treatment Centre Board annual report 2011. [PDF]
, 2012 We are committed to providing effective, high quality and client focused treatment. This is provided in a caring, professional manner, taking account of the individual needs of our clients within a multidisciplinary setting.
core
JIIS: Jurnal Ilmiah Ibnu Sina, 2016 Installation of Hospital Pharmacy perform medication management phase including the selection, planning and procurement. Given the drug management system in Pharmacy Installation Regional Public Hospital (IFRSUD) H.
Mochammad Maulidie Alfiannor Saputera
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Perspectives on drugs: Drug consumption rooms: an overview of provision and evidence. [PDF]
, 2016 Supervised drug consumption facilities, where illicit drugs can be used under the supervision of trained staff, have been operating in Europe for the last three decades.
core
Zhongguo yiliao qixie zazhiObjectiveTo explore the current management status and challenges of brain-computer interface (BCI) rehabilitation medical devices. The existing classification system in China faces several problems, including a single classification dimension ...
Yue WANG +8 more
doaj +1 more source
Frontiers in Pharmacology, 2018 Background: There is conflicting evidence on the impact of biologic treatment on the rate of complications and surgeries in Crohn’s disease (CD). We aimed to assess real-world consequences of biologic treatment of CD.Methods: All adult patients with CD ...
Przemysław Holko +3 more
doaj +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source