Results 171 to 180 of about 5,867,590 (302)

Market Size in Innovation: Theory and Evidence From the Pharmaceutical Industry [PDF]

This paper investigates the effect of (potential) market size on entry of new drugs and pharmaceutical innovation. Focusing on exogenous changes driven by U.S.
Daron Acemoglu, Joshua Linn
core  

Autonomous AI‐Driven Design for Skin Product Formulations

Advanced Intelligent Discovery, EarlyView.
This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang, Yongrui Xiao, Chunlin Chen, Dimitrios Tsaoulidis, Kai Yang, Tao Chen   +5 more
wiley   +1 more source

"You take care of people, people will take care of you": Moral Economies and an Unpredictable Drug Market. [PDF]

PLoS One
Gould EE, Ganesh SS, DiMario AJ, Huh J, Bluthenthal RN, Ceasar RC.   +5 more
europepmc   +1 more source

A Resource-Constrained Optimal Control Model for Crackdown on Illicit Drug Markets [PDF]

In this paper we present a budget-constrained optimal control model aimed at finding the optimal enforcement profile for a street-level, illicit drug crackdown operation.
Haunschmied, J.L., Baveja, A., Feichtinger, G., Hartl, R.F., Kort, P.M.   +4 more
core  

When Biology Meets Medicine: A Perspective on Foundation Models

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence, and foundation models in particular, are transforming life sciences and medicine. This perspective reviews biological and medical foundation models across scales, highlighting key challenges in data availability, model evaluation, and architectural design.
Kunying Niu, Yuxing Wang, Limin Zou, Jing Huang   +3 more
wiley   +1 more source

Navigating US illicit drug market volatility: harm reduction strategies employed by people who inject drugs. [PDF]

Health Promot Int
Winiker AK, Sisson LN, Schneider KE, Rouhani S, Martin EM, Nestadt DF, Silberzahn BE, Zhang L, Footer K, Sherman SG.   +9 more
europepmc   +1 more source

Multi‐Property Machine Learning Models to Accelerate the Transition Toward Bio‐Based Emulsion Polymers

Advanced Intelligent Discovery, EarlyView.
A machine learning framework simultaneously predicts four critical properties of monomers for emulsion polymerization: propagation rate constant, reactivity ratios, glass transition temperature, and water solubility. These tools can be used to systematically identify viable bio‐based monomer pairs as replacements for conventional formulations, with ...
Kiarash Farajzadehahary, Nicholas Ballard   +1 more
wiley   +1 more source

Overdose as a complex contagion: modelling the community spread of overdose events following law enforcement efforts to disrupt the drug market. [PDF]

J Epidemiol Community Health
Humphrey JL, Schwab C, Richardson NJ, Lambdin BH, Kral AH, Ray B.   +5 more
europepmc   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

Budgetary impact of using BPaL for treating extensively drug-resistant tuberculosis

BMJ Global Health, 2022
Christiaan Mulder, Susan van den Hof, Shelly Malhotra, Sarah Cook-Scalise, Sandeep Juneja, Stephan Rupert, Ery Setiawan, Elmira Mambetova, Patience Edo, Jhon Sugiharto, Sani Useni, Imran Pambudi, Abdullaat Kadyrov, Adebola Lawanson, Agnes Gebhard, Hojoon Sohn   +15 more
doaj   +1 more source