Results 271 to 280 of about 6,868,569 (338)
Altered drug metabolism and increased susceptibility to fatty liver disease in a mouse model of myotonic dystrophy. [PDF]
Nat CommunDewald Z +6 more
europepmc +1 more source
Regulation of PXR in drug metabolism: chemical and structural perspectives. [PDF]
Expert Opin Drug Metab ToxicolGee RRF, Huber AD, Chen T.
europepmc +1 more source
Multi-omic analysis of a mucolipidosis II neuronal cell model uncovers involvement of pathways related to neurodegeneration and drug metabolism. [PDF]
Mol Genet MetabBadenetti L +7 more
europepmc +1 more source
The drug disposition in the Spleen: A novel study of CYP and UGT-mediated drug metabolism
Inuwa P +4 more
europepmc +1 more source
Predicting drug metabolism: experiment and/or computation? [PDF]
Nature reviews. Drug discovery, 2015 Drug metabolism can produce metabolites with physicochemical and pharmacological properties that differ substantially from those of the parent drug, and consequently has important implications for both drug safety and efficacy.
J. Kirchmair +7 more
semanticscholar +5 more sources
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Drug Discovery Today, 2020
Proteolysis-targeting chimeras (PROTACs) are an emerging therapeutic modality with the potential to open target space not accessible to conventional small molecules via a degradation-based mechanism; however, their bifunctional nature can result in ...
A. Pike +4 more
semanticscholar +1 more source
Proteolysis-targeting chimeras (PROTACs) are an emerging therapeutic modality with the potential to open target space not accessible to conventional small molecules via a degradation-based mechanism; however, their bifunctional nature can result in ...
A. Pike +4 more
semanticscholar +1 more source
2023
Abstract This chapter discusses drug metabolism as being one of the key steps in pharmacokinetics. Every time your patient receives a drug, a complex process occurs. Absorption, distribution, metabolism, and excretion of a particular drug provide vital information for the treatment of your patients.
Jeske, Theodore, Knezevic, Nebojsa Nick
openaire +3 more sources
Abstract This chapter discusses drug metabolism as being one of the key steps in pharmacokinetics. Every time your patient receives a drug, a complex process occurs. Absorption, distribution, metabolism, and excretion of a particular drug provide vital information for the treatment of your patients.
Jeske, Theodore, Knezevic, Nebojsa Nick
openaire +3 more sources
, 2020
Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences.
M. Coleman
semanticscholar +1 more source
Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences.
M. Coleman
semanticscholar +1 more source
Journal of Natural Products, 1983
Drugs and other chemicals that do not occur in mammalian systems are metabolized by a wide variety of enzymes. Reactions catalyzed by these enzymes have been classified into two general phases. Phase I reactions include oxidations, reductions, and hydrolyses, whereas Phase II reactions are broadly defined as conjugation reactions and include ...
S D, Nelson, W P, Gordon
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Drugs and other chemicals that do not occur in mammalian systems are metabolized by a wide variety of enzymes. Reactions catalyzed by these enzymes have been classified into two general phases. Phase I reactions include oxidations, reductions, and hydrolyses, whereas Phase II reactions are broadly defined as conjugation reactions and include ...
S D, Nelson, W P, Gordon
openaire +2 more sources