Results 281 to 290 of about 6,868,569 (338)

Metabolism, Pharmacogenetics, and Metabolic Drug–Drug Interactions of Antipsychotic Drugs

Cellular and Molecular Neurobiology, 1999
1. Antipsychotic drugs are extensively metabolised by cytochrome P450 (CYP) enzymes. 2. Dispositions of a number of antipsychotic drugs have been shown to cosegregate with polymorphism of CYP2D6. 3. Metabolic drug-drug interactions have frequently been observed when antipsychotics are coadministered with other drugs. 4.
J, Fang, J W, Gorrod
openaire   +2 more sources

In silico approaches and tools for the prediction of drug metabolism and fate: A review

Comput. Biol. Medicine, 2019
The fate of administered drugs is largely influenced by their metabolism. For example, endogenous enzyme-catalyzed conversion of drugs may result in therapeutic inactivation or activation or may transform the drugs into toxic chemical compounds.
Sayada Reemsha Kazmi, Ren Jun, Myeong-Sang Yu, Chanjin Jung, D. Na   +4 more
semanticscholar   +1 more source

Extramicrosomal drug metabolism

European Journal of Drug Metabolism and Pharmacokinetics, 1979
Drug metabolizing enzymes which are not located in the microsomes such as oxidoreductases are reviewed. It has been reported that a cytoplasmic NAD+-dependent dehydrogenase could be involved in the dehydrogenation of secondary or primary alcohols, and that peroxidases, located in all extranuclear cell-fractions, are able to oxidize certain drugs. Among
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Drug metabolism and metabolite safety assessment in drug discovery and development

Expert Opinion on Drug Metabolism & Toxicology, 2018
Introduction: Drug metabolism is one of the most important processes involving a drug after administration. Undesirable pharmacokinetic properties may lead to drug discontinuation.
Chunyong He, Hong Wan
semanticscholar   +1 more source

Drug Metabolism as a Mutation — Drug Metabolism in Mutation

Drug Metabolism Reviews, 1976
(1976). Drug Metabolism as a Mutation — Drug Metabolism in Mutation. Drug Metabolism Reviews: Vol. 5, No. 2, pp. i-ii.
openaire   +2 more sources

Comparative Drug Metabolism

1969
The tradition of testing the poisonous properties of food and drink by administering the material to animals extends back through the history of mankind. In some civilizations the expediency of employing human beings as professional ‘tasters’ was an acceptable practice.
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Drug Metabolism

2020
This chapter highlights one of the significant aspects of the pharmacokinetic phase of drug action, i.e. those factors which control the journey of a drug from initial delivery to its site of action. Drug metabolism can be defined as the chemical alteration of a drug by a biological system, with the principal objective of eliminating the drug from that
openaire   +1 more source

Absorption, distribution, metabolism and excretion of the biomaterials used in Nanocarrier drug delivery systems.

Advanced Drug Delivery Reviews, 2019
Nanocarriers (NCs) are a type of drug delivery system commonly used to regulate the pharmacokinetic and pharmacodynamic properties of drugs. Although a wide variety of NCs has been developed, relatively few have been registered for clinical trials and ...
Chong Su, Yingze Liu, Runzhi Li, Wei Wu, J. P. Fawcett, J. Gu   +5 more
semanticscholar   +1 more source

Aldehyde toxicity and metabolism: the role of aldehyde dehydrogenases in detoxification, drug resistance and carcinogenesis

Drug metabolism reviews (Softcover ed.), 2019
Aldehydes are carbonyl compounds found ubiquitously in the environment, derived from both natural and anthropogenic sources. As the aldehydes are reactive species, therefore, they are generally toxic to the body.
Amaj Ahmed Laskar, H. Younus
semanticscholar   +1 more source

Drug Metabolism

Scottish Medical Journal, 1972
J, McEwen, I H, Stevenson
openaire   +2 more sources