Results 41 to 50 of about 3,469,335 (259)
Molecules, 2023 Polylactic acids (PLAs) are synthetic polymers composed of repeating lactic acid subunits. For their good biocompatibility, PLAs have been approved and widely applied as pharmaceutical excipients and scaffold materials.
Yuyao Zhang +5 more
doaj +1 more source
Crossroads between drug and energy metabolism : role of constitutive androstane receptor and AMP-activated kinase [PDF]
, 2010 Phenobarbital (PB) is a prototype inducer of genes encoding drug metabolizing enzymes including the cytochromes P450 (CYPs). Additionally, phenobarbital was found to repress genes that encode enzymes involved in gluconeogenesis such as ...
Harach, Taoufiq
core +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
In vitro approaches to modelling drug metabolism using capillary electrophoresis [PDF]
, 2003 The focus of this research was to develop improved methods for the analysis of drug metabolism by capillary electrophoresis Coumann was initially chosen as the model for the study, which then broadened in its scope to include the analysis of ammo acids ...
Ward, Eimear
core +2 more sources
CPT: Pharmacometrics & Systems Pharmacology, 2022 As one of the key components in model‐informed drug discovery and development, physiologically‐based pharmacokinetic (PBPK) modeling linked with in vitro‐to‐in vivo extrapolation (IVIVE) is widely applied to quantitatively predict drug–drug interactions (
Shinji Yamazaki +2 more
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Biomedicines, 2023 Metformin plasma exposure is increased in rats with thioacetamide (TAA)-induced liver failure. The absorption, distribution, and excretion process of metformin is mainly mediated by organic cation transporters (OCTs) and multidrug and toxin extrusion ...
Hao Zhi +9 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Phase II Drug Metabolism [PDF]
, 2016 All organisms are constantly and unavoidably exposed to xenobiotics including both man–made and natural chemicals such as drugs, plant alkaloids, microorganism toxins, pollutants, pesticides, and other industrial chemicals. Formally, biotransformation of
Jančová, Petra, Šiller, Michal
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mAbsThe efficacy of therapeutic monoclonal antibodies (mAbs) often hinges on biodistribution to their site of action. However, traditional pharmacokinetic (PK) assessments – typically based on measuring plasma or total tissue concentrations – fail to reflect
Zach Rabow +6 more
doaj +1 more source