Results 21 to 30 of about 3,469,335 (259)
The heterogeneity among subgroups of haplogroup J influencing Alzheimer’s disease risk
Journal of Advanced Research, 2021 Introduction: The impact of mitochondrial haplogroups on Alzheimer’s disease (AD) risk has not been fully elucidated and warrants further investigation at the subgroup level.
HaoChen Liu +4 more
doaj +1 more source
The Aggravation of Clozapine-Induced Hepatotoxicity by Glycyrrhetinic Acid in Rats
Journal of Pharmacological Sciences, 2014 Clozapine (CLZ) was reported to be associated with hepatotoxicity. Glycyrrhetinic acid (GA) has a liver protective effect. Our preliminary experiments showed that GA aggravated rather than attenuated CLZ-induced hepatotoxicity in primary cultured rat ...
Ling-ling Jia +12 more
doaj +1 more source
Emerging new therapeutic antibody derivatives for cancer treatment
Signal Transduction and Targeted Therapy, 2022 Monoclonal antibodies constitute a promising class of targeted anticancer agents that enhance natural immune system functions to suppress cancer cell activity and eliminate cancer cells.
Shijie Jin +7 more
doaj +1 more source
A Novel miRNA Detection Method Using Loop-Mediated Isothermal Amplification
International Journal of Analytical Chemistry, 2023 A novel ligation-based loop-mediated isothermal amplification has been developed for miRNA detection. Two stem-loop structure DNA linker A/B probes which hybridized with miRNA were designed to establish a rapid and ultrasensitive miRNA-LAMP system for ...
Saiwei Wu +4 more
doaj +1 more source
A review of pharmacokinetic parameters of metabolites and prodrugs
, 2014 In drug discovery and development, the kinetic study of active metabolites plays an important role, helping to define the time course of the drug in the body and its activity or toxicity.
Peccinini, Rosângela Gonçalves +2 more
core +3 more sources
Biomedicines, 2021 Liver failure is associated with increased levels of brain aromatic amino acids (AAAs), whose transport across the blood–brain barrier (BBB) is mainly mediated by L-amino acid transporter 1 (LAT1). We aimed to investigate whether liver failure induced by
Xiaoke Zheng +9 more
doaj +1 more source
The effects of fasting on drug metabolism [PDF]
, 2020 Introduction: There is considerable variability in the rates and extent of drug metabolism between patients due to physiological, genetic, pharmacologic, environmental and nutritional factors such as fasting.
Lammers, Laureen A +6 more
core +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2023 In celiac disease (CeD), gastrointestinal CYP3A4 abundance and morphology is affected by the severity of disease. Therefore, exposure to CYP3A4 substrates and extent of drug interactions is altered.
Farzaneh Salem +6 more
doaj +1 more source
Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice [PDF]
Journal of Extracellular Vesicles, 2015 Previous studies using B16BL6-derived exosomes labelled with gLuc–lactadherin (gLuc-LA), a fusion protein of Gaussia luciferase (a reporter protein) and lactadherin (an exosome-tropic protein), showed that the exosomes quickly disappeared from the ...
Takafumi Imai +8 more
doaj +1 more source
Prediction of human drug clearance and anticipation of clinical drug-drug interaction potential from in vitro drug transport studies [PDF]
, 2014 A major concern in drug development is the characterization of new molecular entities (NMEs) with respect to their safety and efficacy. Both factors are determined by the drug’s exposure within the body which itself is affected by drug clearance ...
Kunze, Annett
core +1 more source