Results 11 to 20 of about 3,469,335 (259)

Pharmacokinetics of hydroxymethylnitrofurazone and its parent drug nitrofurazone in rabbits

, 2013
The prodrug hydroximethylnitrofurazone (NFOH) presents antichagasic activity with greatly reduced toxicity compared to its drug matrix nitrofurazone (NF). Besides these new characteristics, the prodrug was more active against the parasite T.
Davanço, Marcelo Gomes [UNESP], Chin, Chung Man, Filho, Marco Antonio Ferraz Nogueira [UNESP], Padilha, Elias Carvalho, Campos, Michel Leandro de, de Campos, Michel Leandro [UNESP], Pestana, Kelly Christina [UNESP], Padilha, Elias Carvalho [UNESP], Chin, Chung Man [UNESP], Nogueira Filho, Marco Antonio Ferraz, Machado, Diego Vinicius de Pontes, Pestana, Kelly Christina, Peccinini, Rosângela Gonçalves [UNESP], de Pontes Machado, Diego Vinicius [UNESP], Davanço, Marcelo Gomes   +14 more
core   +4 more sources

Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection

Journal of Pharmaceutical Health Care and Sciences, 2023
Background Tedizolid is a new oxazolidinone antibiotic with high potency for the treatment of infections caused by methicillin-resistant Staphylococcus aureus and other species.
Daisuke Negishi, Okimichi Mitsumatsu, Hiromi Mitsumatsu, Miaki Makiguchi, Makiko Shimizu, Hiroshi Yamazaki   +5 more
doaj   +1 more source

Impact of Erythrocyte Duffy Antigen Genetic Polymorphism on the Distribution of GroB-T, a Novel Human CXC Chemokine

Journal of Pharmacy & Pharmaceutical Sciences, 2007
Purpose. GroB-T, a human CXC chemokine, has been studied for its potential to mobilize stem cells. Chemokines bind specifically to receptors on target immune cells but also to a homologous erythrocyte blood group antigen, the Duffy Antigen/Receptor for ...
Timothy W Hepburn, LeeAnn P Tobia, Wei Shi, Timothy A McIntyre, Charles B Davis   +4 more
doaj   +1 more source

A peripherally restricted P2Y12 receptor antagonist altered rat tumor incidences with no human relevance: Mode of action consistent with dopamine agonism

Toxicology Reports, 2014
Background: Ticagrelor is an orally available, direct acting and reversible P2Y12 receptor antagonist approved for treatment of acute coronary syndrome.
David A. Brott, Håkan A.S. Andersson, Jane Stewart, Lorna Ewart, Greg Christoph, Johannes Harleman, Duncan Armstrong, Lewis B. Kinter   +7 more
doaj   +1 more source

A Whole-Body Physiologically Based Pharmacokinetic Model Characterizing Interplay of OCTs and MATEs in Intestine, Liver and Kidney to Predict Drug-Drug Interactions of Metformin with Perpetrators

Pharmaceutics, 2021
Transmembrane transport of metformin is highly controlled by transporters including organic cation transporters (OCTs), plasma membrane monoamine transporter (PMAT), and multidrug/toxin extrusions (MATEs).
Yiting Yang, Zexin Zhang, Ping Li, Weimin Kong, Xiaodong Liu, Li Liu   +5 more
doaj   +1 more source

Drug metabolism and liver disease: a drug–gene–environment interaction [PDF]

, 2017
Despite the central role of the liver in drug metabolism, surprisingly there is lack of certainty in anticipating the extent of modification of the clearance of a given drug in a given patient.
Khoueiry-Zgheib, Nathalie, Branch, Robert A.   +1 more
core   +1 more source

Xenobiotic metabolism: the effect of acute kidney injury on non-renal drug clearance and hepatic drug metabolism. [PDF]

, 2014
Acute kidney injury (AKI) is a common complication of critical illness, and evidence is emerging that suggests AKI disrupts the function of other organs.
John Dixon, Philips, B, Dixon, J, Lane, K, Macphee, I, Katie Lane, Barbara Philips, Iain MacPhee   +7 more
core   +1 more source

Pharmacological properties of a novel ACAT inhibitor (CP-113,818) in cholesterol-fed rats, hamsters, rabbits, and monkeys

Journal of Lipid Research, 1994
The novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor CP-113,818 has been characterized in vitro against ACAT isolated from liver and intestine from a variety of species including human subjects, and in vivo in cholesterol-fed rats, hamsters ...
C A Marzetta, Y E Savoy, A M Freeman, C A Long, J L Pettini, R E Hagar, P B Inskeep, K Davis, A F Stucchi, R J Nicolosi   +9 more
doaj   +1 more source

Pharmacokinetic modeling of over-the-counter drug diphenhydramine self-administered in overdoses in Japanese patients admitted to hospital

Journal of Pharmaceutical Health Care and Sciences, 2021
Background Although the over-the-counter H1 receptor antagonist diphenhydramine is not a common drug of abuse, it was recently recognized as one of the substances causing acute poisoning in patients attempting suicide that led to admissions to our ...
Koichiro Adachi, Satoru Beppu, Mariko Terashima, Wataru Kobari, Makiko Shimizu, Hiroshi Yamazaki   +5 more
doaj   +1 more source

Evaluation of dosing strategy for pembrolizumab for oncology indications

Journal for ImmunoTherapy of Cancer, 2017
Background Traditionally, most monoclonal antibodies (mAbs) have been dosed based on body weight because of perceived contribution of body size in pharmacokinetic variability.
Tomoko Freshwater, Anna Kondic, Malidi Ahamadi, Claire H. Li, Rik de Greef, Dinesh de Alwis, Julie A. Stone   +6 more
doaj   +1 more source