Results 221 to 230 of about 86,096 (311)

Assessment of Abuse Potential‐Related Effects of Oral Dried Kratom Leaf Powder in Healthy Normal Participants Following Single and Multiple Daily Doses

open access: yesDrug Testing and Analysis, EarlyView.
In a randomized, double‐blind, placebo‐controlled study of oral dried kratom leaf powder in healthy kratom‐naive adults, no participants met the clinically meaningful opioid withdrawal threshold; abuse‐related treatment‐emergent adverse events occurred more frequently at higher doses but were generally mild and resolved without sequelae; and no serious
Marion Coe   +5 more
wiley   +1 more source

Statistics from the Northern Ireland substance misuse database: 2024/25.

open access: yes
This report presents findings on people presenting to services with problem drug and/ alcohol misuse for the first time, or the first time in six months. The statistics in this report are Official statistics in development (previously called Experimental
McClements, Anne Marie   +2 more
core  

Elimination Profile of Deflazacort and Metabolites in Urine and Plasma Following Oral Administration: Relevance to Sports Drug Testing

open access: yesDrug Testing and Analysis, EarlyView.
Results confirm that the MRL of 30 ng/mL for 21‐desacetyl‐deflazacort together with a 3‐day washout period is an appropriated strategy to detect oral deflazacort administration in sport competition. ABSTRACT Deflazacort (DEF) is a glucocorticoid prohibited in sports competitions when orally administered.
Sergi Coll   +5 more
wiley   +1 more source

Investigations Into the Metabolism and Elimination of Flmodafinil and Fladrafinil for Sports Drug Testing Purposes

open access: yesDrug Testing and Analysis, EarlyView.
This article investigates the metabolism and elimination of flmodafinil and fladrafinil, two fluorinated analogs of modafinil and adrafinil listed as S6 stimulants by the World Anti‐Doping Agency. After single‐dose administration to six volunteers, the compounds and their main metabolites were studied in urine and blood.
O. Krug   +6 more
wiley   +1 more source

Investigations Into the Metabolism and Elimination of Tesofensine in Human Urine

open access: yesDrug Testing and Analysis, EarlyView.
This study investigated tesofensine metabolism and urinary elimination after a single 483 μg intake via a dietary supplement. In six volunteers, urine was collected up to 659 h. LC‐HRMS/MS identified four tentative metabolites; maximum urinary concentrations reached 4 ng/mL within 4–48 h.
O. Krug, A. Thomas, M. Thevis
wiley   +1 more source

Identification of Synthetic Urine by Analysis of Stable Carbon and Nitrogen Isotope Ratios and Comparison to Established GC‐MS/MS and LC‐MS/MS Analysis

open access: yesDrug Testing and Analysis, EarlyView.
This study compared GC‐MS/MS, EA‐IRMS, and LC‐MS/MS for detecting synthetic and manipulated urine samples in doping control and forensic analysis. EA‐IRMS proved particularly effective for identifying mixtures of synthetic and authentic urine, providing a reliable complement to established authenticity testing methods.
Hülsemann Frank   +4 more
wiley   +1 more source

Dietetic‐Led Cognitive‐Behavioral Therapy for Avoidant/Restrictive Food Intake Disorder: Feasibility, Acceptability, and Proof‐of‐Concept

open access: yesInternational Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Cognitive‐Behavioral Therapy for Avoidant/Restrictive Food Intake Disorder (CBT‐AR) is an emerging treatment for ARFID, but to date, it has only been delivered by mental health clinicians. Given the relevance of nutrition to treatment goals, we adapted the treatment to be dietetic‐led (D‐CBT‐AR).
Copeland G. Winten   +6 more
wiley   +1 more source

Trajectories of Prescription Drug Misuse Among US Adults From Ages 18 to 50 Years.

open access: yesJAMA Netw Open, 2022
McCabe SE   +6 more
europepmc   +1 more source

Forecasting heart failure: Seasonal alignment of heart failure outcomes in New York

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 819-831, April 2025.
Abstract Background Seasonal variations have been observed in heart failure (HF) hospitalization. Numerous explanatory mechanisms have been proposed, but no prior studies have examined potential contributors directly. Our objective was to identify specific factors that could contribute to seasonal variability using a large longitudinal dataset of HF ...
Prerna Gupta   +5 more
wiley   +1 more source

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