Results 261 to 270 of about 249,494 (353)
Clinical Pharmacology &Therapeutics, EarlyView.Thiopurine methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) are key enzymes that catabolize thiopurines. Decreased or no‐function alleles in TPMT and NUDT15 are associated with reduced or no enzyme activity and predictive of pronounced adverse effects, including severe myelosuppression, that may occur among individuals treated with standard ...
Maud Maillard +18 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Cannabidiol (CBD) is one of the most abundant bioactive cannabinoids. Research has demonstrated CBD’s ability to inhibit metabolic enzymes like cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT), potentially leading to drug interactions. However, clinical knowledge gaps remain, particularly with regard to drugs that are more commonly taken by ...
Pablo Salcedo +11 more
wiley +1 more source
Where Tech Meets the SDGs: A Supply‐Chain Process Map for Sustainability Management
Corporate Social Responsibility and Environmental Management, EarlyView.ABSTRACT This study investigates how advanced technologies support Sustainable Development Goals (SDGs) within supply chain management (SCM) through a structured analysis of 4448 sustainable practices. By integrating perspectives from sustainability‐oriented innovation (SOI) and contingent dynamic capabilities, the research conceptualizes technology ...
Vincenzo Varriale +2 more
wiley +1 more source
Investigations Into the Human Metabolism of Trestolone (7α‐Methyl‐19‐Nortestosterone)
Drug Testing and Analysis, EarlyView.As the known metabolites of 7α‐methyl‐19‐nortestosterone (MENT), M1 and M2, suffer from chromatographic issues under routine doping control conditions, the human metabolism of MENT was reinvestigated. From the numerous new metabolites detected, especially, M5 and M10 were identified as the most promising candidates to be implemented into routine ...
Thomas Piper +2 more
wiley +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Previous research has revealed negative effects of appearance‐related social media content, such as fitspiration, on body satisfaction. However, specific interventions to reduce these detrimental effects are scarce. Therefore, this randomized controlled pilot trial investigated the efficacy of the four‐week online intervention body ...
Gritt Ladwig +4 more
wiley +1 more source
International Journal of Eating Disorders, EarlyView.ABSTRACT Objective While compulsory treatment is shown to be potentially traumatic for patients, its impact on clinicians has been insufficiently studied. This study aimed to examine clinicians' experiences with providing compulsory nasogastric tube feeding for youth with severe anorexia nervosa, with particular attention to identifying factors ...
T. M. Offringa +6 more
wiley +1 more source
Reviewing and benchmarking ecological modelling practices in the context of land use
Ecography, EarlyView.Despite habitat loss and degradation are the primary drivers of biodiversity loss, different conclusions have been drawn about the importance of land‐use or land‐cover (LULC) change for biodiversity. Differences may be due to the difficulty of framing a coherent model design to assess LULC effects.
Elie Gaget +6 more
wiley +1 more source