Results 121 to 130 of about 8,578,730 (368)

Performance of Cpred/Cobs concentration ratios as a metric reflecting adherence to antidepressant drug therapy [PDF]

, 2011
Background: Nonadherence is very common among subjects undergoing pharmacotherapy for schizophrenia and depression. This study aimed to evaluate the performance of the ratio of the nonlinear mixed effects pharmacokinetic model predicted concentration to ...
Bies, RR, Feng, Y, Frank, E, Gastonguay, MR, Kepple, GH, Pollock, BG   +5 more
core   +2 more sources

Daily cigarette smoking among inpatients for substance use disorders in France, 2010–2020: Commonalities and specificities across substances

Tobacco Induced Diseases
Introduction This study aims to estimate the prevalence and factors associated with cigarette smoking among patients in treatment for substance use disorders (SUD) in France.
Eric Janssen, Mike Vuolo, Guillaume Airagnes   +2 more
doaj   +1 more source

Study of adverse drug reactions of atypical antipsychotic drugs in the department of psychiatry in a tertiary care hospital of Assam

Open Journal of Psychiatry and Allied Sciences, 2017
Objective: To monitor the adverse drug reactions (ADRs) of atypical antipsychotic drugs in the outpatient department (OPD) of psychiatry in Silchar Medical College and Hospital (SMCH) of Assam, and also to find out the causality and severity of ADRs ...
Pinaki Chakravarty, Parthajyoti Neog, Babul Dewan   +2 more
doaj   +1 more source

Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology

Clinical pharmacology and therapy, 2017
Despite the fact that pharmacokinetic exposure of kinase inhibitors (KIs) is highly variable and clear relationships exist between exposure and treatment outcomes, fixed dosing is still standard practice.
R. Verheijen, Huixin Yu, J. Schellens, J. Beijnen, N. Steeghs, A. Huitema   +5 more
semanticscholar   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Initial Development toward Non-Invasive Drug Monitoring via Untargeted Mass Spectrometric Analysis of Human Skin. [PDF]

, 2019
Drug monitoring is crucial for providing accurate and effective care; however, current methods (e.g., blood draws) are inconvenient and unpleasant. We aim to develop a non-invasive method for the detection and monitoring of drugs via human skin.
Bouslimani, Amina, da Silva, Ricardo R, Del Rosario, Krizia K, Dorrestein, Pieter C, Elijah, Emmanuel O, Ernst, Madeleine, Jarmusch, Alan K, Tsunoda, Shirley M, Vargas, Fernando, Wang, Mingxun   +9 more
core   +1 more source

A Novel Long-term, Multi-Channel and Non-invasive Electrophysiology Platform for Zebrafish. [PDF]

, 2016
Zebrafish are a popular vertebrate model for human neurological disorders and drug discovery. Although fecundity, breeding convenience, genetic homology and optical transparency have been key advantages, laborious and invasive procedures are required for
Baraban, Scott C, Hong, SoonGweon, Lee, Luke P, Lee, Philip   +3 more
core   +1 more source

Monitoring Potential Drug Interactions and Reactions via Network Analysis of Instagram User Timelines [PDF]

arXiv, 2015
Much recent research aims to identify evidence for Drug-Drug Interactions (DDI) and Adverse Drug reactions (ADR) from the biomedical scientific literature. In addition to this "Bibliome", the universe of social media provides a very promising source of large-scale data that can help identify DDI and ADR in ways that have not been hitherto possible ...
arxiv  

American Gastroenterological Association Institute Technical Review on the Role of Therapeutic Drug Monitoring in the Management of Inflammatory Bowel Diseases.

Gastroenterology, 2017
Therapeutic drug monitoring (TDM), which involves measurement of drug or active metabolite levels and anti-drug antibodies, is a promising strategy that can be used to optimize inflammatory bowel disease therapeutics.
N. Vande Casteele, H. Herfarth, J. Katz, Y. Falck-Ytter, Siddharth Singh   +4 more
semanticscholar   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source