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Therapeutic drug monitoring

Acta Neuropsychiatrica, 1999
SUMMARYThe cytochrome P450 iso-enzyme system plays a key role in the biotransformation of many drugs, including psychotropics. Its activity is determined by both genetic and environmental factors. The most important iso-enzymes for psychiatry in general are P450 IID6, 3A4 and 1A2.
J B, Noten   +3 more
openaire   +2 more sources

Antiarrhythmic Drug Monitoring

Clinics in Laboratory Medicine, 1981
The classification of antiarrhythmic agents by mechanism of action aids the clinician in selecting appropriate antiarrhythmic drug therapy. The pharmacokinetics, the side effects, and the interpretation of serum levels of quinidine, procainamide, disopyramide, lidocaine, and other agents are discussed.
J H, Howanitz, P J, Howanitz
openaire   +2 more sources

Therapeutic drug monitoring of antiepileptic drugs: current status and future prospects

Expert Opinion on Drug Metabolism & Toxicology, 2020
Introduction: Antiepileptic drugs (AEDs) are the cornerstone of treatment of patients with epilepsy, and there are presently 27 licensed AEDs making AEDs among the most common medications for which therapeutic drug monitoring (TDM) is performed.
Cecilie Johannessen Landmark   +2 more
semanticscholar   +1 more source

Evidence-based Guideline for Therapeutic Drug Monitoring of Vancomycin: 2020 Update by the Division of Therapeutic Drug Monitoring, Chinese Pharmacological Society.

Clinical Infectious Diseases, 2020
BACKGROUND Clinical practice guidelines or recommendations often require timely and regular updating as new evidence emerges, because this can alter the risk-benefit trade-off.
N. He   +53 more
semanticscholar   +1 more source

Blood Levels to Optimize Antipsychotic Treatment in Clinical Practice: A Joint Consensus Statement of the American Society of Clinical Psychopharmacology and the Therapeutic Drug Monitoring Task Force of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie.

Journal of Clinical Psychiatry, 2020
OBJECTIVE The quantification of antipsychotic levels in blood, also known as therapeutic drug monitoring (TDM), is a potentially useful tool of modern personalized therapy that can be applied to augment antipsychotic use and dosing decisions.
G. Schoretsanitis   +18 more
semanticscholar   +1 more source

Free Drug Monitoring

Clinics in Laboratory Medicine, 1987
The principles, technique of measurement, and clinical significance of free drugs are reviewed. Albumin, alpha-1-acid glycoprotein, and lipoprotein are the main drug-binding proteins in blood. Variations of the concentrations of these proteins owing to disease would result in changes in the free drug levels.
S, Chan, B, Gerson
openaire   +2 more sources

Therapeutic Drug Monitoring Can Improve Linezolid Dosing Regimens in Current Clinical Practice: A Review of Linezolid Pharmacokinetics and Pharmacodynamics.

Therapeutic Drug Monitoring, 2020
Linezolid is an antibiotic used to treat infections caused by drug-resistant gram-positive organisms, including vancomycin-resistant Enterococcus faecium, multi-drug resistant Streptococcus pneumoniae, and methicillin-resistant Staphylococcus aureus. The
G. Rao   +5 more
semanticscholar   +1 more source

Therapeutic drug monitoring of antipsychotics.

Psychopharmacology bulletin
Therapeutic drug monitoring of conventional and atypical antipsychotics offers numerous clinical advantages to the clinician. These include cost savings, decreased risk of toxicity, and improved compliance.
Paul J. Perry
semanticscholar   +1 more source

Cancer Chemotherapy: The Case for Therapeutic Drug Monitoring.

Therapeutic Drug Monitoring, 2020
The selection of an appropriate therapy and dosing regimen is a significant challenge in the treatment of cancer. Although there are recommended standardized chemotherapy protocols for some types of cancer, protocol changes usually only occur after large
Claire E. Knezevic, W. Clarke
semanticscholar   +1 more source

Drug level monitoring: cardiovascular drugs

Journal of Chromatography B: Biomedical Sciences and Applications, 1985
Methods for the determination of cardiovascular drugs in blood and plasma are critically reviewed with emphasis on gas and liquid chromatographic techniques. The importance of the various procedures is discussed, in particular sample work-up where the conditions for isolation and derivatization of the compounds are decisive for the accuracy and ...
M, Ahnoff   +4 more
openaire   +2 more sources

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