Results 361 to 370 of about 8,631,498 (387)

Therapeutic drug monitoring

Acta Neuropsychiatrica, 1999
SUMMARYThe cytochrome P450 iso-enzyme system plays a key role in the biotransformation of many drugs, including psychotropics. Its activity is determined by both genetic and environmental factors. The most important iso-enzymes for psychiatry in general are P450 IID6, 3A4 and 1A2.
J B, Noten, W M, Verhoeven, S, Tuinier, D, Touw   +3 more
openaire   +2 more sources

Drug monitoring in the elderly

Clinical Biochemistry, 1986
Although the gut changes markedly with age no important differences in drug absorption have yet been demonstrated for any of a wide variety of drugs. Alterations in body structure and function can have important consequences on drug distribution in the elderly.
openaire   +3 more sources

Monitoring of Drug-Drug and Drug-Food Interactions

American Journal of Health-System Pharmacy, 1988
A program for detecting and preventing potentially serious drug-drug and drug-food interactions is described. Two clinical pharmacists developed drug interaction alert (DIA) cards for each potential interaction to be monitored. The cards contain information about the proposed mechanism and potential result of the interaction, as well as information ...
Susan M. Garabedian-Ruffalo, Patricia M. Lanius, Antoinette Plucinski, Margo Syrja-Farber   +3 more
openaire   +3 more sources

Polymeric Nanoparticles with a Glutathione-Sensitive Heterodimeric Multifunctional Prodrug for In Vivo Drug Monitoring and Synergistic Cancer Therapy.

Angewandte Chemie, 2018
Polymeric micelle-based drug delivery systems have dramatically improved the delivery of small molecular drugs, yet multiple challenges remain to be overcome.
Fuwu Zhang, Qianqian Ni, Orit Jacobson, Siyuan Cheng, Arthur Liao, Zhantong Wang, Zhimei He, Guocan Yu, Jibin Song, Ying Ma, G. Niu, Longjiang Zhang, G. Zhu, Xiaoyuan Chen   +13 more
semanticscholar   +1 more source

Therapeutic Drug Monitoring of the Antimycobacterial Drugs

Clinics in Laboratory Medicine, 1996
Because MDR tuberculosis and MAC are difficult to treat, TDM with the antimycobacterial drugs has become the standard of practice at NJC. By combining specific and sensitive assays, carefully collected samples, and clinical expertise, we are able to control and optimize antimycobacterial drug therapy.
openaire   +3 more sources

Problems in Therapeutic Drug Monitoring

Therapeutic Drug Monitoring, 1988
Historically, it has been assumed that only free drug concentration is the pharmacologically active species. This article reviews the theoretical pharmacological and pharmacokinetic justifications for monitoring free drug levels. The determinants likely to influence plasma protein binding and the free concentrations of drugs are delineated.
François Delion, Frédéric Didey, Jérôme Barré, Jean-Paul Tillement   +3 more
openaire   +3 more sources

Recent advances in analytical methods for the therapeutic drug monitoring of immunosuppressive drugs.

Drug Testing and Analysis, 2018
Therapeutic drug monitoring (TDM) of immunosuppressive drugs (ISDs) with a narrow therapeutic index is an increasingly popular tool for minimizing drug toxicity while maximizing the prevention of graft loss and organ rejection.
Yu Zhang, Rui Zhang
semanticscholar   +1 more source

Pharmacokinetic and pharmacodynamic drug monitoring of direct acting oral anticoagulants: Where do we stand?

Therapeutic Drug Monitoring, 2019
For decades, oral anticoagulation has been based on vitamin K antagonist such as warfarin, which requires pharmacodynamic drug (PD) monitoring to guide the therapy.
E. Wieland, M. Shipkova
semanticscholar   +1 more source

Therapeutic Drug Monitoring of Voriconazole

Therapeutic Drug Monitoring, 2008
Voriconazole is a triazole antifungal developed for the treatment of life-threatening fungal infections in immunocompromised patients. The drug, which is available for both oral and intravenous administration, has broad-spectrum activity against pathogenic yeasts, dimorphic fungi, and opportunistic molds.
Bruggemann, R.J.M., Donnelly, J.P., Aarnoutse, R.E., Warris, A., Blijlevens, N.M.A., Mouton, J.W., Verweij, P.E., Burger, D.M.   +7 more
openaire   +4 more sources

Drug Monitoring (Spiegelbestimmungen)

1996
Serumspiegelbestimmungen von Antibiotika sind sinnvoll 1. zur Kontrolle, ob therapeutisch wirksame Konzentrationen erreicht werden 2. um bei Antibiotika mit geringer therapeutischer Breite toxische Nebenwirkungen zu vermeiden.
Jürgen Biscoping, Roswitha Füssle, Andreas Sziegoleit   +2 more
openaire   +2 more sources