An individual-based dynamic model to assess interventions to mitigate opioid overdose risk
Harm Reduction JournalBackground Illicit opioid overdose continues to rise in North America and is a leading cause of death. Mathematical modeling is a valuable tool to investigate the epidemiology of this public health issue, as it can characterize key features of population
Kirsten Gallant, Ryan Lukeman
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Leveraging Large Language Models for Multi-Class and Multi-Label Detection of Drug Use and Overdose Symptoms on Social Media [PDF]
arXivDrug overdose remains a critical global health issue, often driven by misuse of opioids, painkillers, and psychiatric medications. Traditional research methods face limitations, whereas social media offers real-time insights into self-reported substance use and overdose symptoms.
arxiv
Drug-Related Mortality and Fatal Overdose Risk: Pilot Cohort Study of Heroin Users Recruited From Specialist Drug Treatment Sites in London [PDF]
, 2003 Matthew Hickman
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British Journal of Clinical Pharmacology, EarlyView.Aims Several methods exist to identify hospital admissions related to adverse drug events (ADEs). Clinical adjudication by healthcare professionals is the gold standard but is labour‐intensive. Spontaneous reporting and routinely collected healthcare data using a set of International Classification of Diseases (ICD) codes often underestimate the ...
Zuzana Juhásová +2 more
wiley +1 more source
Attitudes About Prescribing Take-Home Naloxone to Injection Drug Users for the Management of Heroin Overdose: a Survey of Street-Recruited Injectors in the San Francisco Bay Area [PDF]
, 2003 Karen H. Seal
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Deciphering the skeletal interoceptive circuitry to control bone homeostasis
BMEMat, EarlyView.This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu +7 more
wiley +1 more source
Promising Prodiginins Biological Activities
Chemistry &Biodiversity, EarlyView.ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto +6 more
wiley +1 more source
, 2018 Heroin is an opioid that commonly appears as white or brown powder. Eventually a person can become physically dependent on heroin, meaning the body begins to expect the drug.
Drew, Margaret M.
core
Clinical Pharmacology in Drug Development, EarlyView.Abstract This small phase 1C, open‐label, single ascending dose study evaluated the safety, tolerability, and pharmacokinetics (PKs) of DM199, a recombinant form of human tissue kallikrein‐1 (KLK1). A small sample size of both healthy subjects and hypertensive adults recently taking angiotensin‐converting enzyme inhibitors was studied. KLK1 has a known
Michael Giuffre +3 more
wiley +1 more source
Interaction between infusion equipment resulting in drug overdose in a critically ill patient [PDF]
, 2004 Radha Sundaram, Alissa Dell
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