Results 171 to 180 of about 6,265,118 (288)

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Association between prior ICU admission for drug overdose and ICU readmission: A retrospective registry-based study. [PDF]

Crit Care Resusc
Wu M, Subramaniam A, Ling RR, Secombe P, Bailey M, Pilcher D.   +5 more
europepmc   +1 more source

Acute Modafinil Exposure Induces Neurobehavioral Alterations in Zebrafish: Implications for Off‐Label Cognitive Enhancement

Journal of Applied Toxicology, EarlyView.
ABSTRACT Modafinil (2‐(benzhydrylsulfinyl)acetamide) is a psychostimulant commonly prescribed for sleep disorders such as narcolepsy, excessive daytime sleepiness, and obstructive sleep apnea. Recently, its use has extended beyond clinical indications, with neurotypical individuals adopting it as a smart drug to enhance alertness and cognitive ...
Luciane Dellazari da Silva do Prado, Nicole Berton, Nicoli da Rosa Amaral, Inara Carbonera Biazus, Laíse Mattiollo, Jéssica Nardi, Karen Júlia de Souza dos Santos, Natália Freddo, Leonardo José Gil Barcellos, Luciana Grazziotin Rossato‐Grando   +9 more
wiley   +1 more source

Association of short-term ambient environmental exposures with suicide and drug overdose deaths among U.S. veterans. [PDF]

Am J Epidemiol
Peluso A, Lamichhane D, VanDerslice JA, Logan J, Kapadia A, Trafton JA, Bakian AV.   +6 more
europepmc   +1 more source

Surveillance Report:Highlights from the Annual Surveillance Report of Drug-Related Risks and Outcomes United States, 2018 [PDF]

These slides contain selected data from the second annual surveillance report summarizing the latest information at the national level for prescribing patterns, drug use, and nonfatal and fatal overdose related to the current drug overdose epidemic ...

core  

The Link Between Opioid Misuse and Suicidal Ideation Is Strongest Among Sexual Minorities

Journal of Clinical Psychology, EarlyView.
ABSTRACT Opioid misuse and suicidal ideation (SI) are significant public health concerns in the United States, and incidence rates may be elevated among sexual minority people. We used data from the 2021 National Survey on Drug and Health (heterosexual, n = 39,647, lesbian/gay n = 1329, bisexual n = 3774) to investigate rates of opioid misuse and ...
Katherine Musacchio Schafer, Rachel M. Schott, Julia C. Dodd, Jameson K. Hirsch   +3 more
wiley   +1 more source

Rethinking responses to over-the-counter drug overdose among young people in Japan: Toward a low-threshold support architecture. [PDF]

Glob Health Med
Ujihara M, Iwasawa A, Watanabe M.
europepmc   +1 more source

Response to Ng et al. on “Stimulus‐induced arousal with transient electroencephalographic improvement distinguishes nonictal from ictal generalized periodic discharges”

Epilepsia, EarlyView.
Philippe Gélisse, William O. Tatum, Arielle Crespel, Peter W. Kaplan   +3 more
wiley   +1 more source

Addressing in‐hospital substance use: A bioethical evaluation of two possible approaches

Journal of Hospital Medicine, EarlyView.
Abstract Up to 40% of patients with substance use disorder report using non‐prescribed drugs when hospitalized. In‐hospital substance (IHSU) use is associated with poor outcomes and raises safety concerns for healthcare providers. Despite its prevalence, little guidance exists regarding best practices in responding to IHSU.
John C. Messinger, Taylor Baisey, Johanna Sluser, Benjamin A. Barsky, Marlene Martin, Leslie W. Suen   +5 more
wiley   +1 more source

Non-fatal drug overdose surveillance using hospital discharge data: a comparison between the Drug Overdose Surveillance and Epidemiology (DOSE) system and the Healthcare Cost and Utilisation Project, 18 states, 2018-2020. [PDF]

Inj Prev
Quader ZS, Park J, Krishnan SD, Stokes E, Pickens CM.   +4 more
europepmc   +1 more source