Results 191 to 200 of about 6,265,118 (288)

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

A chain of survival for drug overdose. [PDF]

Resusc Plus
Dernbach MR, Dasgupta N, Sibley AL, Tylleskar I, Skulberg AK.   +4 more
europepmc   +1 more source

Drug overdose deaths in 28 states and the District of Columbia : 2020 data from the State Unintentional Drug Overdose Reporting System

Key findings:\u2022 Two overarching COVID-19-related themes were identified among overdose decedents\u2022 during January\u2013June 2020: physical and mental impacts of the pandemic and missed touchpoints or opportunities for intervention.\u2022 Commonly

core  

Ranavirus risk depends on host community characteristics more than the presence of Batrachochytrium dendrobatidis

Oikos, EarlyView.
Novel parasite introductions are threatening wildlife communities globally. The degree of threat depends on the ecological context, namely host community characteristics and the presence of other parasites. How these two factors interact to shape the outcomes of parasite introductions is not known. We experimentally investigated how infection following
David R. Daversa, Andy Fenton, Lola M. Brookes, Gonçalo M. Rosa, Chris Sergeant, Trenton W. J. Garner   +5 more
wiley   +1 more source

Mechanistic Evaluation of Luteolin in Wound Healing of Diabetic Foot Ulcer via Nrf2 Signaling

Phytotherapy Research, EarlyView.
Proposed mechanism by which Luteolin (LU) promotes diabetic foot ulcer healing. LU attenuates hyperglycemia‐induced oxidative stress and lipid peroxidation, improves endothelial cell viability, and suppresses ferroptosis through Nrf2‐dependent antioxidant signaling, thereby accelerating angiogenesis and wound repair. ABSTRACT Diabetic foot ulcers (DFUs)
Muhammed Yusuf, Ayfer Busra Benkli, Ramiz Yusuf   +2 more
wiley   +1 more source

Methylene Blue Rescue Therapy for Vasoplegic Shock After Antihypertensive Drug Overdose. [PDF]

Am J Case Rep
Aqel YHI, Karayem MMJ, Rahhal A, Hasan Koya S, Abusal AM, George S.   +5 more
europepmc   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

Organizing across cognitive asymmetry in human–AI collaboration: A study of perfume creation

Strategic Management Journal, EarlyView.
Abstract Research Summary As organizations increasingly adopt generative AI (GenAI), they face a strategic challenge: not only deciding which tasks AI should perform, but also how to organize the integration of human and AI efforts to produce viable solutions.
Tomoko Yokoi, Daniella Laureiro‐Martinez, Federico Magni, Stefano Brusoni   +3 more
wiley   +1 more source

Predicting drug overdose and death after "before medically advised" hospital discharge. [PDF]

CMAJ
Naik H, Daly-Grafstein D, Hu X, Khan M, Kaasa BM, Brubacher JR, Nasmith T, Lyden JR, Moe J, Crabtree A, Slaunwhite AK, Staples JA.   +11 more
europepmc   +1 more source

Protein Corona Engineering of Lipid Nanoparticles Enables Efficient Functional Gene Silencing in the Liver

Small, EarlyView.
By shaping the protein corona, lipid composition directs LNP tropism and enables the preferential delivery of a TIMP1‐targeting siRNA to liver macrophages. In a murine model of primary biliary cholangitis, this strategy promoted macrophage reprogramming and attenuated liver fibrosis.
Naths G. Sukubo, Serena Renzi, Martina B. Violatto, Leila Altigieri, Anna L. Capriotti, Andrea Cerrato, Aldo Laganà, Luca Digiacomo, Erica Quagliarini, Antonio Minopoli, Massimiliano Papi, Daniela Pozzi, Carlo A. Scirè, Pietro Invernizzi, Paolo Bigini, Giulio Caracciolo   +15 more
wiley   +1 more source