Results 201 to 210 of about 3,856,896 (414)

High‐Throughput Drug Derivatization and Bioassay by Desorption Electrospray Ionization Mass Spectrometry

ChemPlusChem, EarlyView.
Accelerated drug derivatization in microdroplets combined with high‐throughput desorption electrospray ionization mass spectrometry provides rapid reaction screening and label‐free bioassay results, which can expedite drug discovery. Adapting high‐throughput (HT) synthetic methods to the modification of drugs and to testing of their bioactivity should ...
Jyotirmoy Ghosh, Nicolás M. Morato, Yunfei Feng, R. Graham Cooks   +3 more
wiley   +1 more source

Mobility-GCN: a human mobility-based graph convolutional network for tracking and analyzing the spatial dynamics of the synthetic opioid crisis in the USA, 2013-2020 [PDF]

arXiv
Synthetic opioids are the most common drugs involved in drug-involved overdose mortalities in the U.S. The Center for Disease Control and Prevention reported that in 2018, about 70% of all drug overdose deaths involved opioids and 67% of all opioid-involved deaths were accounted for by synthetic opioids.
arxiv  

Impact of Age and Factor Xa Inhibitor Concentrations on Bleeding Risk in Patients with Atrial Fibrillation

Clinical Pharmacology &Therapeutics, EarlyView.
This study aimed to analyze differences in the exposure‐response relationship for factor Xa inhibitors (FXaI) between patients aged ≥ 80 and < 80 years. Patients with atrial fibrillation (AF) taking rivaroxaban, apixaban, or edoxaban were enrolled, and a single steady‐state trough concentration was measured.
Shin‐Yi Lin, Yen‐Bing Liu, Li‐Ting Ho, Ching‐Hua Kuo, Yu‐Fong Peng, Chih‐Fen Huang, Sung‐Chun Tang, Jiann‐Shing Jeng   +7 more
wiley   +1 more source

Adverse drug reactions as cause of admission to hospital: Definition of adverse drug reactions needs to include overdose [PDF]

, 2004
M. Barton Laws
openalex   +1 more source

Characteristics of methadone related overdose deaths and comparisons between those dying on and off methadone substitution treatment: a national cohort study. [PDF]

Background: Opioid users, particularly those with a history of injecting and dependence, have a high risk of fatal polysubstance and methadone related overdose.
Barry, A, Collins, C, Crowley, D, Delargy, I, van Hout, MC   +4 more
core  

First‐in‐Human Single and Multiple Ascending Dose Studies of Balinatunfib, a Small Molecule Inhibitor of TNFR1 Signaling in Healthy Participants

Clinical Pharmacology &Therapeutics, EarlyView.
Oral small molecule inhibitors of tumor necrosis factor alpha (TNFα) are emerging as attractive therapeutic agents for the treatment of various autoimmune diseases. Balinatunfib (SAR441566), a novel oral inhibitor of tumor necrosis factor receptor 1 (TNFR1) signaling, changes the configuration of the soluble TNFα (sTNFα) trimer and prevents its ...
Nassr Nassr, Faiza Rharbaoui, Dietmar Weitz, Johann Gassenhuber, Markus Rehberg, Markus Kohlmann, Fabienne Schumacher, Amel Lahmar, Andreas Kovar, Laurent Perrin, Frank‐Dietrich Wagner, Maria Wiekowski, Mai Anh Nguyen   +12 more
wiley   +1 more source

Estimating changes in overdose death rates from increasing methamphetamine supply in Ohio: Evidence from crime lab data

Drug and Alcohol Dependence Reports
Background: We investigate the relationship between the supply of methamphetamine and overdose death risk in Ohio. Ohio and the overall US have experienced a marked increase in overdose deaths from methamphetamine combined with fentanyl over the last ...
Daniel Rosenblum, Jeffrey Ondocsin, Sarah G. Mars, Dennis Cauchon, Daniel Ciccarone   +4 more
doaj  

Detoxication capacity of a multiple (w/o/w) emulsion for the treatment of drug overdose. II. Detoxication of quinine sulfate with the emulsion in the gastro-intestinal tract of rabbits.

, 1982
Yasunori Morimoto, Yukiya Yamaguchi, Kenji Sugibayashi   +2 more
openalex   +2 more sources

Alemtuzumab Exposure and T Lymphocyte Depletion: A Population Pharmacokinetic‐Pharmacodynamic Model of Alemtuzumab Induction Therapy for Kidney Transplantation

Clinical Pharmacology &Therapeutics, EarlyView.
Alemtuzumab is a T cell‐depleting monoclonal antibody that is used for the prevention of kidney transplant rejection. The duration of lymphodepletion after the current standard induction therapy dose is likely longer than necessary, resulting in prolonged T cell lymphopenia with the associated risk of infections. Here, the interplay between alemtuzumab
Lukas K. van Vugt, Tom C. Zwart, Suzanne Bezstarosti, Sebastiaan Heidt, Marlies E. J. Reinders, Dennis A. Hesselink, Aiko P. J. de Vries, Brenda C. M. de Winter, Dirk Jan A. R. Moes   +8 more
wiley   +1 more source

Associations among drug acquisition and use behaviors, psychosocial attributes, and opioid-involved overdoses

BMC Public Health
Aims This study sought to develop and assess an exploratory model of how demographic and psychosocial attributes, and drug use or acquisition behaviors interact to affect opioid-involved overdoses.
James A. Swartz, Peipei Zhao, Ross Jacobucci, Dennis P. Watson, Mary Ellen Mackesy-Amiti, Dana Franceschini, A. David Jimenez   +6 more
doaj   +1 more source