Results 71 to 80 of about 1,920,311 (233)

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

open access: yesAdvanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang   +19 more
wiley   +1 more source

Factors associated with adverse clinical features in patients presenting with non-fatal self-poisoning

open access: yes, 2011
Background: Drug overdose or self poisoning is an important reason for an ambulance service response. We aimed to undertake a preliminary investigation into the pattern of drug overdose presenting to one ambulance service and factors associated with ...
Deborah Shaw (16053866)   +4 more
core   +5 more sources

A Ten-Year Study of Drug Poisoning Cases Admitted to the Intensive Care Unit of 5 Azar Hospital in Gorgan, Iran

open access: yesJournal of Clinical and Basic Research, 2019
Background and objectives: Drug poisoning is a serious global health problem that sometimes requires hospitalization and intensive care. This study investigates clinical and demographic profile of acute poisoning cases admitted to the intensive care unit
Mohammad Shokrzadeh   +6 more
doaj  

Ti‐Doping Activates Adjacent Zr Sites in Bimetallic MOFs for Cooperative Phospholipid Removals in Human Biomonitoring

open access: yesAdvanced Science, EarlyView.
Ti‐doped Zr/Ti bimetallic MOFs activate neighboring Zr sites to selectively capture phospholipids from serum through cooperative interactions. In nontargeted screening, the material minimizes matrix interference, expands detectable feature coverage, and enables broad recovery of diverse chemical hazards, providing a powerful cleanup strategy for LC ...
Yanmin Liang   +5 more
wiley   +1 more source

EPIDEMIOLOGICAL STUDY OF DRUG INTOXICATION IN CHILDREN [PDF]

open access: yesActa Medica Iranica, 2006
Unintentional drug intoxication is still a major cause of morbidity and mortality in young children. In order to study the epidemiological pattern of childhood drug poisoning in Golestan province, all cases diagnosed with poisoning from 1997 to 2002 in ...
F. Cheraghali M. Taymori
doaj   +2 more sources

Clinical profile and outcomes of childhood poisoning

open access: yesBangabandhu Sheikh Mujib Medical University Journal, 2017
The patterns of accidental poisoning in children usually differ from country to country and from one region to another within the same country. This retrospective study was performed from January 2012 to December 2014 to determine the trends of childhood
Farzana Ahmed   +2 more
doaj   +1 more source

HSE reports rise in cocaine poisoning cases.

open access: yes, 2019
Almost 100 people were diagnosed with non-fatal cocaine poisoning last year in Ireland, new figures released by the HSE show. This statistic adds to evidence of the increased prevalence of the drug, following a report last week that suggested Ireland had
Sheahan, Emily
core  

Facet‐Dependent Activity of Fe3S4 Crystal in Peroxydisulfate Activation for Organic Pollutants Degradation

open access: yesAdvanced Science, EarlyView.
Fe3S4 crystal with the exposed [001] facet exhibits higher catalytic activity for activating peroxydisulfate (PDS) to degrade clothianidin (CLO), which can be attributed to the dissolved Fe‐induced homogeneous catalytic process; while Fe3S4 crystal with the exposed [1‐21] facet exhibits excellent catalytic stability and durability, thereby boosting the
Jiaqu Tan   +6 more
wiley   +1 more source

A retrospective analysis of the impact of toxicological diagnostics on clinical decision making in cases of acute drug poisoning

open access: yesEmergency Care Journal, 2017
The outcome of acute drug poisoning is good. In only a few occasions specific treatments are needed. Toxicological screenings are recommended when acute drug poisoning is suspected.
Janne H. Liisanantti   +2 more
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

open access: yesAdvanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries   +25 more
wiley   +1 more source

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