Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium
Advanced Science, EarlyView.This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du +5 more
wiley +1 more source
The Opium Wars, Opium Legalization, and Opium Consumption in China [PDF]
The effect of drug prohibition on drug consumption is a critical issue in debates over drug policy. One episode that provides information on the consumption-reducing effect of drug prohibition is the Chinese legalization of opium in 1858.
Chris Feige, Jeffrey A. Miron
core
Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia
Advanced Science, EarlyView.Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen +19 more
wiley +1 more source
"It's a Bit of a Double-Edged Sword": Motivation and Personal Impact of Bereaved Mothers' Advocacy for Drug Policy Reform. [PDF]
Qual Health Res, 2021 Morris H +4 more
europepmc +1 more source
Advanced Science, EarlyView.This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang +10 more
wiley +1 more source
The use of mathematical modeling to inform drug policy making. [PDF]
Int J Drug Policy, 2021 Martin NK, Vickerman P.
europepmc +1 more source
Researching Hard-to Reach Populations: Privileged Access Interviewers and Drug Using Parents [PDF]
Accessing drug using populations is notoriously fraught with difficulties for researchers (Gurdin & Patterson, 1987; Griffiths, Gosspo & Strang, 1993; Renzetti & Lee, 1993; Spreen & Zwaagstra, 1994; Goode, 2000; Elliott et al., 2002).
Jackie Kearney, Nicola Jane Taylor
core
Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development
Advanced Science, EarlyView.Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu +8 more
wiley +1 more source
Harm Minimisation Drug Policy Implementation Qualities: Their Efficacy with Australian Needle and Syringe Program Providers and People Who Inject Drugs. [PDF]
Healthcare (Basel), 2022 Resiak D, Mpofu E, Rothwell R.
europepmc +1 more source
Design and Characterization of DX‐Tile DNA Nanostar‐Based Hydrogels
Advanced Science, EarlyView.In this study, the authors demonstrated that DNA DX‐tile‐based multi‐arm motifs can be used to assemble pure DNA hydrogels, offering greater design flexibility and enhanced control over their mechanical properties and functionalization capabilities compared to single duplex‐based DNA hydrogels.
Dylan V. Scarton +13 more
wiley +1 more source