Results 21 to 30 of about 195,352 (95)
Approach for delabeling beta-lactam allergy in children
Frontiers in Allergy, 2023 A considerable number of pediatric patients treated with beta-lactam (BL) antibiotics develop delayed onset of skin rashes during the course of treatment.
R. Sáenz de Santa María +14 more
doaj +1 more source
Principled Drug-Drug Interaction Terms for Bayesian Logistic Regression Models of Drug Safety in Oncology Phase I Combination Trials [PDF]
arXiv, 2023 In Oncology, trials evaluating drug combinations are becoming more common. While combination therapies bring the potential for greater efficacy, they also create unique challenges for ensuring drug safety. In Phase-I dose escalation trials of drug combinations, model-based approaches enable efficient use of information gathered, but the models need to ...
arxiv
Clinical and Translational Allergy, 2022 Among 74 patients with an immediate hypersensitivity reaction (IHR) to iodinated contrast media (ICM), the rate of allergic patients confirmed by positive prick test or diluted intradermal test (IDT) was 8.1%. 12.5% of re‐exposed patients had a recurrent
Juliette Caron +2 more
doaj +1 more source
DDI Prediction via Heterogeneous Graph Attention Networks [PDF]
arXiv, 2022 Polypharmacy, defined as the use of multiple drugs together, is a standard treatment method, especially for severe and chronic diseases. However, using multiple drugs together may cause interactions between drugs. Drug-drug interaction (DDI) is the activity that occurs when the impact of one drug changes when combined with another.
arxiv
Hypersensitivity to Intravenous Iron Preparations
Children, 2022 Intravenous iron is widely used for the treatment of iron deficiency anemia when adherence to oral iron replacement is poor. Acute hypersensitivity reactions during iron infusions are very rare but can be life threatening.
Silvia Caimmi +12 more
doaj +1 more source
Relational graph convolutional networks for predicting blood-brain barrier penetration of drug molecules [PDF]
arXiv, 2021 Evaluating the blood-brain barrier (BBB) permeability of drug molecules is a critical step in brain drug development. Traditional methods for the evaluation require complicated in vitro or in vivo testing. Alternatively, in silico predictions based on machine learning have proved to be a cost-efficient way to complement the in vitro and in vivo methods.
arxiv
The efficiency of multi-target drugs: the network approach might help drug design [PDF]
Trends in Pharmacological Sciences 26, 178-182 (2005), 2004 Despite considerable progress in genome- and proteome-based high-throughput screening methods and rational drug design, the number of successful single target drugs did not increase appreciably during the past decade. Network models suggest that partial inhibition of a surprisingly small number of targets can be more efficient than the complete ...
arxiv +1 more source
Allergology International, 2022 Background: Skin rash often occurs upon oral administration of amoxicillin in children, due to non-immediate hypersensitivity. However, information on delayed hypersensitivity to amoxicillin is scarce.
Yukiko Katoh +5 more
doaj
Drug Interaction Vectors Neural Network: DrIVeNN [PDF]
arXiv, 2023 Polypharmacy, the concurrent use of multiple drugs to treat a single condition, is common in patients managing multiple or complex conditions. However, as more drugs are added to the treatment plan, the risk of adverse drug events (ADEs) rises rapidly. Many serious ADEs associated with polypharmacy only become known after the drugs are in use.
arxiv
Fixed drug eruption due to clarithromycin
Journal of Research in Pharmacy Practice, 2013 Fixed drug eruption (FDE) is an unusual adverse effect of any drug, especially antibiotics like clarithromycin. Herein we report a case of clarithromycin induced FDE in a 30-year-old man who presented with recurrent erythematous and pruritic cutaneous ...
Santoshi Balkrishna Malkarnekar +1 more
doaj +1 more source