Results 61 to 70 of about 195,352 (95)

Discovering Synergistic Drug Combinations for COVID with Biological Bottleneck Models [PDF]

arXiv, 2020
Drug combinations play an important role in therapeutics due to its better efficacy and reduced toxicity. Recent approaches have applied machine learning to identify synergistic combinations for cancer, but they are not applicable to new diseases with limited combination data. Given that drug synergy is closely tied to biological targets, we propose a \
arxiv  

Challenging dogmas: Intravenous versus oral beta-lactam antibiotic provocation tests

World Allergy Organization Journal
Background: Drug provocation tests (DPT) are considered the gold standard procedure to ascertain the diagnosis of beta-lactam (BL) allergy. Regarding route of administration, current recommendations prioritize oral challenges, considering them safer, and
Gustavo-Jorge Molina-Molina, MD, Manuel Gómez-Duque, MD, Xavier Vidal Guitart, MD, PhD, Antònia Agustí Escasany, MD, PhD, Moisés Labrador-Horrillo, MD, PhD, Olga Luengo, MD, PhD, Anna Sala-Cunill, Paula Galvan-Blasco, MD, Mar Guilarte, MD, PhD, Victoria Cardona, MD, PhD   +9 more
doaj  

Non-Pharmacological Management of Neurocardiogenic Syncope

Journal of Arrhythmia, 2007
Neurocardiogenic syncope is a common disorder. It is diagnosed by obtaining a detailed history and performing a head-up tilt test, with or without drug provocation. Several studies have been performed pertaining to its management.
Haruhiko Abe, MD FACC, Ritsuko Kohno, MD, Masataka Sumiyoshi, MD, Yasushi Oginosawa, MD, Hiroko Takemasa, MD, Takuo Tsurugi, MD, Toshihisa Nagatomo, MD, Yutaka Otsuji, MD FACC   +7 more
doaj   +1 more source

Stable Drug Designing By Minimizing Drug Protein Interaction Energy Using PSO [PDF]

arXiv, 2015
Each and every biological function in living organism happens as a result of protein-protein interactions.The diseases are no exception to this. Identifying one or more proteins for a particular disease and then designing a suitable chemical compound (known as drug) to destroy these proteins has been an interesting topic of research in bio-informatics.
arxiv  

High occurrence of simultaneous multiple-drug hypersensitivity syndrome induced by first-line anti-tuberculosis drugs

World Allergy Organization Journal, 2021
Background: Multiple drug hypersensitivity syndrome (MDHS) results in treatment delay or failure and often results in severe drug hypersensitivity reactions.
Da Woon Sim, Hye Su You, Ji Eun Yu, Young-Il Koh   +3 more
doaj  

Severe exacerbation of facial dermatitis with swelling following introduction of abrocitinib in a patient with atopic dermatitis

Allergy, Asthma & Clinical Immunology
Background Abrocitinib, an oral small-molecule Janus kinase 1 (JAK1) inhibitor, has been widely accepted for the treatment of moderate-to-severe atopic dermatitis (AD).
Shirui Chen, Chongtu Yang, Yonghong Lu
doaj   +1 more source

Drug provocation tests (DPTs) of contrast media: Useful or not useful? – A narrative review

World Allergy Organization Journal
Drug provocation tests (DPTs) are also used in some patients with a history of a contrast medium (CM)-hypersensitivity reaction. Since the use of contrast agents requires special knowledge that is present in radiology but not necessarily in allergology ...
Manuel Dettwiler, MMed, Ingrid B. Boehm, MD   +1 more
doaj  

Safety evaluation of a buffer used in the lyophilization of canine platelets: type I hypersensitivity reaction in dogs caused by bovine serum albumin

Frontiers in Veterinary Science
IntroductionThe present study was designed to evaluate the safety of substances generally used in the preparation of lyophilized platelet products (LPPs) because the possibility of an immune response to bovine serum albumin (BSA) was considered high when
Hee-Jae Choi, Mu-Young Kim, Hyun-Jung Han, Hyun-Jung Han   +3 more
doaj   +1 more source

Editorial: Diagnosis and management of allergy to chemotherapy and biologics

Frontiers in Allergy, 2023
Ricardo Madrigal-Burgaleta, Mariana Castells   +1 more
doaj   +1 more source

Outcomes of drug provocation tests in children with chronic complications and comorbidities: Case series

Journal of Allergy and Clinical Immunology: Global
A study demonstrated that drug provocation tests could be conducted in children with underlying diseases, enabling accurate diagnosis of drug allergy.
Kouhei Hagino, MD, Kiwako Yamamoto-Hanada, MD, PhD, Seiko Hirai, MD, Daisuke Harama, MD, PhD, Marei Omori, MD, Yasuaki Matsumoto, MD, Daichi Suzuki, MD, Kotaro Umezawa, MD, Fumi Ishikawa, MD, Kenji Toyokuni, MD, PhD, Tatsuki Fukuie, MD, PhD, Yukihiro Ohya, MD, PhD   +11 more
doaj