Constructing HIV/AIDS in Chinese media (2010-2024): A mixed-methods study. [PDF]
PLoS OneLi Y, Wu C, Yu L, Shi H.
europepmc +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Biosample Donation Intentions of Patients with Infectious Disease Based on the Theory of Planned Behavior: A Qualitative Study. [PDF]
Infect Drug ResistWang W +9 more
europepmc +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Mount Gambier, the Lake District of South Australia [picture] /
, 1930 Poster promoting Mount Gambier in South Australia as a tourist destination.; Poster signed: Goodchild.; Logo of: Govt. Publicity and Tourist Bureau, South Australia.; "Information from all tourist bureaux & travel agencies in all States"; Exhibited ...
Goodchild, John C. (John Charles), 1898-1980.
core
The impact of social influence and perceived value on usage intention of county-level "Internet + Medical Health" services: a moderating analysis of region. [PDF]
Front Digit HealthZhao L, Wei L, Zhang Q, Tian R.
europepmc +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Results from the first clinical trial of bitopertin for steroid-relapsed/refractory Diamond-Blackfan anemia. [PDF]
Blood Red Cells IronYoung DJ +8 more
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Characteristics of pediatric drug-related investigator-initiated trials in Chinese children's hospitals: a comparative analysis based on ChiCTR and ClinicalTrials.gov registration data. [PDF]
Front PharmacolYang Y, Zhang D, Yang S, Yao Z.
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