Results 81 to 90 of about 1,839,920 (311)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Long Beach Fire Department publicity photo

open access: yes, 1956
Publicity photo of stylized fire truck mounted on cabinet door at unknown ...

core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Taking stock: A decade of drug policy - A civil society shadow report. [PDF]

open access: yes, 2018
Taking stock: A decade of drug policy’ evaluates the impacts of drug policies implemented across the world over the past decade, using data from the United Nations (UN), complemented with peer-reviewed academic research and grey literature reports from ...

core  

Analysis of the current situation of clinical trials of ophthalmic drugs in children based on the common diseases of pediatric ophthalmology in hospital

open access: yesYanke Xuebao
[Objective:] Combined with the common diseases of pediatric ophthalmology in our hospital, the current situation of clinical trials of ophthalmic preparations for children in China was investigated to provide reference for the development of clinical ...
HUANG Yingying   +4 more
doaj   +1 more source

Determination and Prioritizing of Addiction Prevention Factors in Delfan City, Iran [PDF]

open access: yesAddiction and Health, 2011
Background: In recent decades, drug abuse has been one of the most important problems of human societies and has been imposing enormous charges to them.
Davod Mirzaei   +2 more
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Report of a Working Party on Drug Abuse [PDF]

open access: yes, 1971
To examine the extent of drug abuse in Ireland at present to advise the Minister on the steps which must be taken to deal with the problem, including measures to discourage young people from starting the use of drugs(e.g.
Working Party on Drug Abuse
core  

Drug use among secondary school students, New South Wales, 1986

open access: yes, 2019
This survey has a number of objectives: to monitor the nature and extent of alcohol and other drug use; to provide data from which the need for social policy and educational initiatives could be determined; and to provide background data to facilitate ...
NSW Drug and Alcohol Authority
core   +1 more source

Indústria do conhecimento: uma poderosa engrenagem

open access: yesRevista de Saúde Pública
O artigo aborda a articulação da indústria farmacêutica à indústria do conhecimento, por meio de poderosas estratégias de marketing. Com o objetivo de legitimar cientificamente seus produtos, a indústria interfere na produção de conhecimento médico ...
Vera Regina da Silva Miguelote   +1 more
doaj  

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