Results 211 to 220 of about 4,801,266 (265)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Toxic epidermal necrolysis-like linear IgA bullous dermatosis as a manifestation of multiple drug hypersensitivity in the setting of drug reaction with eosinophilia and systemic symptoms

JAAD Case Reports
Scott Stratman, MD, MPH, Lisa Zhou, MD, Randie H. Kim, MD, Robert G. Phelps, MD, Jacob Glickman, MD, Daniela Mikhaylov, MD, Jianni Wu, MD, Nour El-Kashlan, MD, Ryan Rivera-Oyola, MD, Jonas A. Adalsteinsson, MD, PhD, Melissa A. Levoska, MD, Nicholas Gulati, MD, PhD   +11 more
doaj   +1 more source

Allopurinol-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome: A Case Report and Review of the Published Evidence From India. [PDF]

Cureus
Shinde A, Thorat VM, Jamale V, Gaikwad SD, Panda B.   +4 more
europepmc   +1 more source

Inebilizumab in AQP4‐Seropositive NMOSD: One‐Year Follow‐Up From a Multicenter, Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Real‐world evidence on inebilizumab among neuromyelitis optica spectrum disorder (NMOSD) patients is lacking. This study assessed inebilizumab among Chinese patients with aquaporin 4 autoantibody (AQP4‐IgG)‐seropositive NMOSD in a real‐world setting.
Mengcui Gui, Jiayang Zhan, Wei Li, Tao Jin, Dan He, Daishi Tian, Zhijun Li, Jing Lin, Yue Li, Hongyu Zhou, Bitao Bu   +10 more
wiley   +1 more source

Allopurinol-Induced Eosinophilic Colitis as the Dominant and Initial Manifestation of Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome. [PDF]

Cureus
Costa Monteiro S, Vieira R, Bravo S, Henriques J.   +3 more
europepmc   +1 more source

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Drug Reaction with Eosinophilia and Systemic Symptoms in the Electronic Medical Record.

Int Arch Allergy Immunol
Jiang M, Lam L, Kovoor J, Inglis JM, Shakib S, Yuson C, Ali SB, Bacchi S, Kern JS, Sidhu S, Smith W.   +10 more
europepmc   +1 more source

Knowledge, Attitude, and Practice Toward Adverse Drug Reaction Reporting Among Community Pharmacists From the Pilgrimage City of South India: A Cross-Sectional Study. [PDF]

Health Sci Rep
Thammisetty DP, Minnekanti D, Mandem G, Pokuri V, Syed H, Bommireddy BR, Goruntla N.   +6 more
europepmc   +1 more source

Ofatumumab Therapy and Long‐Term Seizure Outcomes of Patients With Relapsing Anti‐NMDA Receptor Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There is a lack of studies on seizure outcomes associated with ofatumumab therapy in patients for relapsing anti‐N‐methyl‐D‐aspartate (NMDA) receptor encephalitis. We aimed to evaluate long‐term seizure outcomes of ofatumumab therapy for relapsing anti‐NMDA receptor encephalitis.
Jian Wang, Mengjiao Li, Ping Kong
wiley   +1 more source

Trends in adverse drug reaction reporting by dentists: a 15-year analysis of German pharmacovigilance data. [PDF]

Clin Oral Investig
Halling F, Lutz R, Meisgeier A.
europepmc   +1 more source