Results 41 to 50 of about 1,787,106 (336)

Valproic acid-induced eosinophilic pleural effusion: An uncommon occurrence

Lung India, 2023
A 43-year-old male using valproic acid (VA) for 2 years for seizure disorder presented with right-sided moderate pleural effusion. Pleural fluid analysis revealed exudative effusion with 42% eosinophils. There was no evidence of haemothorax, pneumothorax,
Manisha Bhardwaj, Pratibha Himral, Surender Kashyap   +2 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

A National Adverse Drug Reaction Reporting System for Malta [PDF]

, 2004
The mission of the Medicines Authority (MA) in Malta is to contribute to protection of public health through regulation of the safety, quality and efficacy of medicines for human use on the local market and to ensure that healthcare professionals and ...
Arthur, Niamh, Bonett, Michael, Vella Bonanno, Patricia   +2 more
core  

The development and use of novel iridium complexes as catalysts for ortho-directed hydrogen isotope exchange reactions [PDF]

, 2010
The preparation and application of groups of new iridium complexes are described. In particular, iridium complexes possessing phosphine ligands and a bulky N-heterocyclic carbene have been shown to be robust and readily handled species and have been ...
Atzrodt, Barakzai, Brown, Bushby, Chen, Crabtree, Cross, Ellames, Ellames, Ellames, Garman, Gupta, Göttker-Schnetmann, Hesk, Heys, Heys, Heys, Heys, Hickey, Krüger, Lee, Leitner, Lockley, Moulton, Powell, Prechtl, Salter, Salter, Salter, Schou, Shu, Shu, Singleton, Skaddan, Skaddan, Träff, van der Boom, Vasquez-Serrano, Voges, Vásquez-Serrano, Wang, Yung, Zhao   +42 more
core   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Reactive granulomatous dermatitis: case series

Journal of the Egyptian Women’s Dermatologic Society, 2020
The terms “palisaded neutrophilic and granulomatous dermatitis” and the subset “interstitial granulomatous drug reaction”, all have been overlapping terms for long time.
Galal El Enany, Noha Nagui, Hanan Nada, Marwa M Fawzy, Iman Sany, Ahmad Nada, Sally S Doss, Omar El Ghanam, Hagar El Sayed   +8 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Tertiary alkylamines as nucleophiles in substitution reactions at heteroaromatic halide during the synthesis of the highly potent pirinixic acid derivative 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS-121) [PDF]

, 2011
YS-121 [2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid] is the result of target-oriented structural derivatization of pirinixic acid.
Gabler, Matthias, Schubert-Zsilavecz, Manfred   +1 more
core   +2 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source