Results 1 to 10 of about 915,020 (267)

An inflammation-responsive therapeutic gel for precise microbiota modulation in colitis

Journal of Nanobiotechnology
Microbiome dysbiosis is a hallmark of inflammatory bowel disease (IBD), and its reprogramming represents a promising intervention strategy. Existing treatments are often limited by gastrointestinal instability and non-specific microbial toxicity, leading
Yanchen Liu, Yang Liu, Wenpeng Huang, Yazhou Liu, Jian Sun   +4 more
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Accurate Identification of Protein Binding Sites for All Drug Modalities Using ALLSites

Advanced Science
Proteins interact with diverse molecular modalities, yet the incomplete identification of their binding sites has left the proteome‐wide druggability largely underexplored.
Minjie Mou, Mingkun Lu, Zhimeng Zhou, Yanlin Ren, Xinyuan Yu, Ziqi Pan, Yuan Zhou, Hao Yang, Lingyan Zheng, Shukai Gu, Yang Zhang, Wei Hu, Fengcheng Li, Haibin Dai, Feng Zhu   +14 more
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Endothelial Cell‐Based Vascular Bandages for Blood–Brain Barrier Repair and Targeted siRNA Delivery

Advanced Science
Changes in the blood‐brain barrier (BBB) are key targets for mitigating cerebral ischemia/reperfusion injury. The rapid progression of reperfusion injury necessitates the development of carriers that target and regulate early BBB disruption, while ...
Yaosheng Li, Yunfei Dong, Yaode He, Juanjuan Zheng, Hui Liu, Lu Li, Xiaoxu Hao, Yanli Zhao, Zefeng Yang, Yuankai Sun, Zhiwei Du, Bo Zhao, Weihang Zhou, Honghui Wu, Tianyuan Zhang, Jiahe Wu, Xiangrui Liu, Xianzhen Yin, Zhicai Chen, Rui Xue, Min Lou, Zhen Gu, Xinchi Jiang, Jianqing Gao   +23 more
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Self-Assembled Nanoparticles of Silicon (IV)–NO Donor Phthalocyanine Conjugate for Tumor Photodynamic Therapy in Red Light

Pharmaceutics
The combination of photodynamic therapy (PDT) and pneumatotherapy is emerging as one of the most effective strategies for increasing cancer treatment efficacy while minimizing side effects. Photodynamic forces affect nitric oxide (NO) levels as activated
Kadireya Aikelamu, Jingya Bai, Qian Zhang, Jiamin Huang, Mei Wang, Chunhong Zhong   +5 more
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A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science
Mitochondrial quality is crucial for maintaining brain homeostasis. BNIP3L/NIX, a mitophagy receptor, has been linked to neurological disorders, yet its specific function in the brain remains unclear.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
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NK‐Cell‐Derived Extracellular Vesicles Engineered to Carry Senolytics Eliminate Chemotherapy‐Induced Senescent Osteosarcoma Cells

Journal of Extracellular Vesicles
Osteosarcoma (OS) is a type of bone tumour characterized by high risk of metastatic progression and recurrence after therapy. Traditional tumour treatment methods such as radiotherapy and chemotherapy can lead to the accumulation of senescent cells in ...
Xianlin Yue, Jie Cui, Shifeng Ren, Yajun Zhang, Ying Li, Hongjuan Cui, Johnny Huard, Paul D. Robbins, Xiaodong Mu   +8 more
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[Drug releasing stents].

Archivos de cardiologia de Mexico, 2003
Drug eluting stents have become a mainstream in the treatment of coronary heart disease. Implementation of this technology into medical practice has resulted in a dramatic reduction in restenosis rates and late loss, which in turn is reflected in a significant reduction in MACE events due predominantly to a reduction in the need of a new re ...
openaire   +1 more source

Microneedle Patch for In Situ Neutrophil Monitoring

Advanced Science
Monitoring neutrophil levels plays an essential role in diagnosing infections and various diseases, as well as for managing specific treatments such as chemotherapy and radiotherapy. However, the traditional complete blood count technique is invasive and
Ziyi Lu, Ruisi Cai, Tianao Xie, Sheng Zhao, Sarun Juengpanich, Win Topatana, Shijie Li, Jiasheng Cao, Jiahao Hu, Tianen Chen, Jiachen Chen, Jicheng Yu, Tao Sheng, Wentao Zhang, Hao Wang, Jiahuan You, Yukai Shan, Yuchao Sun, Ruijing Shen, Zhengjie Zhao, Kangfan Ji, Ziqi Gao, Xinmin Yu, Xiujun Cai, Zhen Gu, Yuqi Zhang, Mingyu Chen   +26 more
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Interpretation of RNA Universe and Coding Potential Using IntRNA

Advanced Science
The interpretation of RNA universe and coding potential are long‐standing issues in modern RNA studies, and three crucial questions remain unanswered: a) how to detect and interpret the coding potential of RNA, b) how to annotate the sophisticated ...
Yunxia Wang, Minjie Mou, Shijie Huang, Wei Zhang, Ziqi Pan, Jing Tang, Yihao Wang, Qingxia Yang, Feng Zhu   +8 more
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Extracellular vesicles for delivering therapeutic agents in ischemia/reperfusion injury

Asian Journal of Pharmaceutical Sciences
Ischemia/reperfusion (I/R) injury is marked by the restriction and subsequent restoration of blood supply to an organ. This process can exacerbate the initial tissue damage, leading to further disorders, disability, and even death. Extracellular vesicles
Weihang Zhou, Xinchi Jiang, Jianqing Gao
doaj   +1 more source