Results 1 to 10 of about 3,939,397 (309)

On-demand pH-sensitive surface charge-switchable polymeric micelles for targeting Pseudomonas aeruginosa biofilms development

Journal of Nanobiotechnology, 2021
Bacterial biofilm is the complicated clinical issues, which usually results in bacterial resistance and reduce the therapeutic efficacy of antibiotics.
Xiangjun Chen, Rong Guo, Changrong Wang, Keke Li, Xinyu Jiang, Huayu He, Wei Hong   +6 more
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Elaboration on the architecture of pH-sensitive surface charge-adaptive micelles with enhanced penetration and bactericidal activity in biofilms

Journal of Nanobiotechnology, 2021
Background Biofilm formation is one of the main reasons for persistent bacterial infections. Recently, pH-sensitive copolymers have fascinated incredible attention to tackle biofilm-related infections.
Rong Guo, Keke Li, Baocheng Tian, Changrong Wang, Xiangjun Chen, Xinyu Jiang, Huayu He, Wei Hong   +7 more
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Modular assembly of indole alkaloids enabled by multicomponent reaction

Nature Communications, 2023
Indole alkaloids are one of the largest alkaloid classes, proving valuable structural moiety in pharmaceuticals. Although methods for the synthesis of indole alkaloids are constantly explored, the direct single-step synthesis of these chemical entities ...
Jiaming Li, Zhencheng Lai, Weiwei Zhang, Linwei Zeng, Sunliang Cui   +4 more
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Design and Synthesis of Novel α-Methylchalcone Derivatives, Anti-Cervical Cancer Activity, and Reversal of Drug Resistance in HeLa/DDP Cells

Molecules, 2023
In this study, a collection of newly developed α-methylchalcone derivatives were synthesized and assessed for their inhibitory potential against human cervical cancer cell lines (HeLa, SiHa, and C33A) as well as normal human cervical epithelial cells (H8)
Zheng Yang, Zhengye Liu, Mourboul Ablise, Aikebaier Maimaiti, Aizitiaili Aihaiti, Yusupuwajimu Alimujiang   +5 more
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Nano Composite Fe-Co-V /Zeolite as a Nano Carrier for Folic Acid Drug Controlled Release [PDF]

Trends in Pharmaceutical Sciences, 2021
large reserves of zeolites has been one of the comparative advantages of the country in this field and provides economic justification for its use in a variety of applications, including medical and pharmaceutical fields such as artificial kidney ...
Shima Zangeneh Yousef Abadi, Mohammad Kazem Mohammadi, Haman Tavakkoli   +2 more
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Hydrogel-Based Microneedle as a Drug Delivery System

Pharmaceutics, 2023
The skin is considered the largest and most accessible organ in the human body, and allows the use of noninvasive and efficient strategies for drug administration, such as the transdermal drug delivery system (TDDS).
David Filho, Marcelo Guerrero, Manuel Pariguana, Adolfo Marican, Esteban F. Durán-Lara   +4 more
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A Transformer-Based Ensemble Framework for the Prediction of Protein–Protein Interaction Sites

Research, 2023
The identification of protein–protein interaction (PPI) sites is essential in the research of protein function and the discovery of new drugs. So far, a variety of computational tools based on machine learning have been developed to accelerate the ...
Minjie Mou, Ziqi Pan, Zhimeng Zhou, Lingyan Zheng, Hanyu Zhang, Shuiyang Shi, Fengcheng Li, Xiuna Sun, Feng Zhu   +8 more
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Airway administered artificial mitochondria-enriched nanovesicles for efficient and selective mitochondria transfer to intervene in pulmonary fibrosis

Nature Communications
Mitochondrial transplantation is a promising therapeutic approach involving the transfer of exogenous mitochondria into diseased cells to restore impaired mitochondrial homeostasis.
Jinsong Zhang, Siying Fu, Jiawen Wang, Honghui Wu, Zhuoting Li, Ruyi Lin, Hao Sun, Seungho Choe, Yuhuan Kong, Donghang Xu, Jinqiang Wang, Zhen Gu, Jianqing Gao, Tianyuan Zhang   +13 more
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Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation

Nature Communications
Fully targeted mRNA therapeutics necessitate simultaneous organ-specific accumulation and effective translation. Despite some progress, delivery systems are still unable to fully achieve this.
Kexin Su, Lu Shi, Tao Sheng, Xinxin Yan, Lixin Lin, Chaoyang Meng, Shiqi Wu, Yuxuan Chen, Yao Zhang, Chaorong Wang, Zichuan Wang, Junjie Qiu, Jiahui Zhao, Tengfei Xu, Yuan Ping, Zhen Gu, Shuai Liu   +16 more
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Periodic asymmetric field enhances electrofusion of nanoscale lipid systems

Nature Communications
Electrofusion is a widely used technique for inducing membrane merging in biological systems, with applications ranging from hybrid lipid architectures to therapeutic delivery.
Honghui Wu, Wen-Che Liu, Xuanyu Wu, Zhuoting Li, Jialu Zhang, Jiawen Wang, Qing Zhu, Jinsong Zhang, Kairu Dong, Ruyi Lin, Huihui Hu, Junjie Zeng, Jiaying Wu, Kan Li, Kewang Nan, Tianyuan Zhang, Jianqing Gao   +16 more
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