Results 201 to 210 of about 915,020 (267)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

The Optimal Amount of PAMAM G3 Dendrimer in Polyurethane Matrices Makes Them a Promising Tool for Controlled Drug Release. [PDF]

Polymers (Basel)
Zaręba M, Twardowska MZ, Błoniarz P, Lechowicz JB, Czechowicz J, Łysik D, Rzepna M, Uram ŁS.   +7 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Novel pH-responsive pectin-based hybrid smart hydrogels for in vitro drug release and in vivo wound healing applications. [PDF]

RSC Adv
Manzoor H, Arshad N, Qureshi MAUR, Qadar S.   +3 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Progress in Hyaluronan-Based Nanoencapsulation Systems for Smart Drug Release and Medical Applications. [PDF]

Molecules
Valachová K, Hassan ME, Tamer TM, Šoltés L.   +3 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Dual-thermo-responsive microneedle patch for accelerated diabetic wound healing through on-demand drug release and active temperature management. [PDF]

J Nanobiotechnology
Xia D, Wu Y, Xu R, Zhou L, Wu X, Wang D, Liang C, Li N.   +7 more
europepmc   +1 more source

PEDOT:PSS-Loaded Gelatin Cryogels for Electrically Controlled Drug Release. [PDF]

ACS Omega
Chen HA, Lee CY, Huang BJ, Tu KY, Sung PH, Hoang LN, Tseng CL.   +6 more
europepmc   +1 more source

A DNA Nanomachine Modulates the Stemness-Associated Signaling Pathways for Overcoming Chemoresistance by Temporally Programming Drug Release. [PDF]

Research (Wash D C)
Chen J, Li X, Chen Q, Zhou X, Zeng J, Guo L, Zhang Y, Yang D, Zhang C.   +8 more
europepmc   +1 more source