Results 201 to 210 of about 935,473 (268)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Influence of plasticizer type on the structure and drug release characteristics of LM-pectin hydrogels. [PDF]

Turk J Chem
Kocaağa B, Güner FS.
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

<i>In Vitro</i> Drug Release Kinetics and Antioxidant Activity of Metformin-Loaded Niosomes. [PDF]

ACS Omega
Çalışkan EE, Aydın YÇ, Ozbek EN, Alcın I, Kilinc E, Yetik Anacak G, Cetin Uyanikgil EO.   +6 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Enhanced Control of Liposomal Drug Release by Drug-Aptamer Complexes. [PDF]

Adv Mater
Huang X, Li Y, Torre M, Shao R, Zhang W, Wang Z, Kohane DS, Weldon CB.   +7 more
europepmc   +1 more source

pH-responsive selenium nanoplatform for targeted drug release and immune remodeling in microbiota-associated colorectal cancer. [PDF]

J Nanobiotechnology
Ma H, Zhang L, Wang L, Liu J, Sun H, Ge S, Liu B, Quan C.   +7 more
europepmc   +1 more source

Ultrasound-Sensitive Liposomal Exatecan for Tumor-Specific Drug Release for Treatment of Pancreatic Cancer. [PDF]

Pharmaceutics
Kim D, Moon H, Han S, Lee HJ.
europepmc   +1 more source

Sequential drug-release microsphere system for scarless wound healing. [PDF]

Mater Today Bio
Luo D, Huang L, Bai B, Zhang H, Liu W, Wen B, Lu Z, Pu X, Chen Q, Shen Z, Li M.   +10 more
europepmc   +1 more source

Film-Forming Gels for Topical Drug Delivery: A Systematic Review of the Effects of Formulation on Film Performance, Drug Release, and Skin Permeation. [PDF]

Drug Des Devel Ther
Firmansyah F, Budiman A, Muchtaridi M, Chabib L, Syaputri FN, Afandi F, Elamin KM, Mohammed AFA, Wathoni N.   +8 more
europepmc   +1 more source